The History Behind Absorption Systems' Transporters and CellPort Analytics™

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The History Behind Caco-2
The application of Caco-2 cells in research was pioneered in the late 1980s by Ismael Hidalgo, Co-Founder and Chief Scientific Officer of Absorption Systems. When cultured under specific conditions, the cells become differentiated and polarized such that their phenotype resembles the enterocytes lining the small intestine. Confluent Caco-2 cell monolayers possess tight gap junctions and are commonly used to evaluate cellular permeability and potential transporter-drug interactions. Our Caco-2 clone (C2BBe1) has been shown as a strong predictor of human outcomes (IVIVC) which allows us to support BCS Biowaivers and obviate costly human clinical trials.
The History of CellPort Analytics
CellPort Analytics was developed as a software-based tracking system that captures and summarizes all cell line manufacturing and performance information into a single data domain. This novel system allows a comprehensive look at historical production characterization of all our cell lines, providing confidence in the data that supports your studies.
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Paralleled performance monitoring across hundreds of batches by proprietary CellPort Analytics™
Quality programs for the most stringently selected test systems 
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Benefits of CellPort Analytics:
Electronic Capture of Lab Data Assures Quality and Reproducibility of CellPort Cells

  • Monitors Cell Assay Plate History from Cryovial to QC
  • Tracks Routine Manipulations to Cells: Media, Feedings, Subculture
  • Allows for Trend Analysis of all Aspects of Assay Plate Performance
  • QC Data Captured, Analyzed and Stored Electronically
  • Barcoding, Electronic Signatures and Audit Trail for all Aspects of Cell Culture
  • Records all Reagent Information: Catalog & Lot Numbers
  • Fully Validated System

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The Absorption Systems Difference

  • Stably-transfected cell lines for consistent expression and function
  • CellPort Analytics® tracking assures batch-to-batch consistency and optimized conditions
  • Rigorous assay designs mitigate the impact of other variables, such as compound stability, nonspecific binding, matrix interference, cytotoxicity, non-linearity, and recovery

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Studies performed in commercially-sourced test systems, including primary cells (such as hepatocytes and kidney proximal tubule cells), vesicles and additional cell lines are also available. Contact us for more details >>
For more information on CellPort Analytics, please view the resources below:

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