Transporters

Great results begin with reliable test systems, which is why we developed CellPort AnalyticsTM Drug Transporter cell lines. Your studies are performed in validated test systems, supported by our experienced staff who offer regulatory-focused guidance from first consultation through final submission.

CellPort Test Systems

Premium quality expression systems for superior accuracy and precision

Caco-2 (C2BBe1) OCT2-HEK293 OATP1B3-HEK293 MATE1-HEK293 NTCP-HEK293
MDR1-MDCK OCT1-HEK293 OATP1A2-HEK293 MATE2K-HEK293 PepT1 (C2BBe1)
BCRP-MDCK OAT3-HEK293 OATP2A1-HEK293 BSEP-Vesicles Custom Development
OCT1-HEK293 OATP1B1-HEK293 OATP2B1-HEK293 MRP2-Vesicles

Regulatory Requirements

CellPort Assay Services

Off-the-shelf and Custom Designs for Maximum Utility at Every Stage of Development

  Discovery/IND-Enabling Definitive/NDA-Enabling
DESIGN    
System Compatibility None Comprehensive
Assay Rigor Basic Advanced

ASSESSMENTS
   
Substrate Single Concentration Multiple Concentrations Inhibitor Challenge, Km/Vmax
Inhibition SingleConcentration Multiple Concentrations, IC50

CellPort Validation

Extensively characterized test systems using the most clinically-relevant substrates and inhibitors for complete regulatory confidence.

Cell Line Substrate Inhibitor
MDR1 Digoxin , Etoposide, Fexofenadine, Amprenavir, Talinolol, Loperamide Valspodar, Cyclosporin A, Vinblastin, Ketoconazole, Loperamide
BCRP Cladribine, Topotecan, Prazosin, Cimetidine, Sulfasalazine, Mitoxantrone, Actinomycin D, Doxorubicin, Estrone-3-Sulfate, Etoposide, Irinotecen, Rosuvastatin, Daunorubicin, SN-38, Fexofenadine Ko143, Elacridar, FTC
OCT1 MPP+, Amantadine, Amiloride, Metformin, Pindolol, Procainamide, Propanolol, Ranitidine Repaglinide, Disopyramide, Quinine, Quinidine, Cimetidine, Rosiglitazone, Triethylamine, Metformin
OCT2 MPP+, Pindolol, Ranitidine, Procainamide, Amiloride, Amantadine Imipramine, TPA, Verapamil, Quinidine, Cimetidine, Metformin, Dopamine, Triethylamine
OAT1 PAH, Adefovir, Cidofovir, Furosemide, Lamivudine, Tenofovir, Zidovudine Probenecid, Bumetanide, Novobiocin, Quinaprilat, TEA, Methotrexate, Lamivudine
OAT3 Furosemide, Bumetanide, Cefaclor, Quinaprilat Probenecid, Bumetanide, Novobiocin, Quinaprilat, Rosuvastatin, Naproxen
OATP1B1 Atorvastatin, Rosuvastatin, Pitavastatin Rifamycin SV, Atenolol, Cyclosporin A, Digoxin, Estrone-3-Sulfate, Estradiol-17β Glucuronide, Ketoconazole, Propranolol, Rifampicin, Ritonavir, Rosuvastatin, Taurocholic Acid, Tolbutamide, Verapamil
OATP1B3 Atorvastatin, Pitavastatin, Rosuvastatin Rifamycin SV, Rifampicin, Rosuvastatin, Taurocholic Acid, Ritonavir, Cyclosporin A, Estradiol-17β Glucuronide, Estrone-3-Sulfate, Atenolol, Propranolol, Digoxin
Mate1 Metformin, MPP+, Cimetidine, Amiloride Cimetidine, Atenolol, Triethylamine, Amantadine, Imipramine, Disopyramide, MPP+, Verapamil, Quinidine, Ritonavir
Mate2K Metformin, MPP+, Cimetidine, Amiloride Pyrimethamine, Ondansetron, Quinidine
MRP2 CDCF MK571
BSEP [3H] Taurocholic acid Cyclosporin A, Troglitazone 

Visit our online store to view protocols, purchase transporter assays or request a custom study design.  

Visit our online store to view protocols, purchase transporter assays or request a custom study design.