We employ biomimetic oxidations to generate Phase I metabolites via non-enzymatic catalysis. Basically, it’s a protein-free, heme-like catalyst. In the presence of an oxygen donor such as H
2O
2, a reactive species is generated that can insert oxygen into a parent compound.
“Absorption Systems helped us solve a difficult problem with an innovative, quick, and cost-effective solution. Through the use of biomimetic oxidation, they were able to quickly produce enough of a target drug metabolite to help us figure out which of two isomers to synthesize “the old-fashioned way.”
– Bradley Wolfe, Ph.D., CMC Development Scientist II, SuperGen, Inc.
In another case, one of our lead scientists was named as co-inventor of international patent by our client in acknowledgment of our crucial contribution into synthesis and characterization of the pharmacologically active metabolite.