SMALL MOLECULE

Our NDA-enabling portfolio of preclinical drug discovery and drug development services includes rigorous and definitive assays in all areas of ADMET, often triggered by specific requests from a regulatory agency. We have an extensive history of performing late-stage studies to support successful NDA submissions, mainly related to toxicology or drug-drug interactions. Our philosophy of utilizing the same validated in vitro test systems across the board, with different levels of rigor, ensures that results will be consistent from screening through NDA.

Drug Discovery & Development Services

• Bioanalytical

  Screening to Fully Validated GLP Bioanalysis Our bioanalytical services expertise provides quantitative measurements on a range of active drugs, from small molecules to peptides, as well as metabolites. We can perform analysis […]

• In Vitro Dissolution Absorption System (IDAS)

  Biopharmaceutics Dissolution with Better In Vivo Correlation The In Vitro Dissolution Absorption System (IDASTM) combines traditional dissolution testing with a means to determine and quantify interactions with a bio-relevant membrane.  IDAS provides the ability to evaluate absorption, […]

• Transporters

  Great results begin with reliable test systems, which is why we developed CellPort AnalyticsTM Drug Transporter cell lines. Your studies are performed in validated test systems, supported by our experienced staff […]

• Physical Properties & Dose Vehicle Development

  Solubility Assessment (bio-buffers and formulation excipients) Log D and Log P Measurements Dissolution Testing Chemical Stability Dose Vehicle Development & Evaluation: Excipient Selection API – Compatibility Vehicle – Suitability Stability […]

• Pharmacokinetics

  Complete study support from formulation to PK parameters. Rapid turnaround to support drug discovery. Experienced team with more than 30 years supporting DMPK. End to End In-life with Bioanlaytical Support. […]

• Ocular

  Pre-clinical Ocular Testing Optimized Ocular Models Focused on Improving Outcomes Our nonclinical ocular models include in vivo and ex vivo options for implants, small and large molecules. Absorption Systems provides specialized tissue-based ADME ocular […]

• Metabolism

  Metabolism is the enzymatic modification of drugs and other xenobiotics, usually to increase clearance. It is a determinant of oral bioavailability, clearance, and half-life in vivo. Metabolism occurs predominantly in the […]

• Protein and Tissue Binding

  Allows prediction of in vivo drug concentration in blood Identifies appropriate fluid medium for pharmacokinetic studies Help determine the extent of distribution of a drug in vivo Plasma Protein Binding […]

• Permeability

  Cell-Based CACO-2 clone C2BBe1 MDR1-MDCK MDCK BCRP-MDCK   Different cell lines are used as in vitro models for different purposes. Caco-2 cell monolayers predict not only intestinal absorption but also drug-drug interactions […]

• Preclinical Toxicology Services

  Preclinical Toxicology Services   Start your safety and tox program with a strong strategy that anticipates issues and avoids costly delays.  From pharmacokinetics through safety/tox assessments, Absorption Systems has the […]

• Drug Delivery Services

  View our extensive capabilities within Preclinical Drug Delivery services. We provide a complete pharmacokinetic evaluation for each study. Formulation Dissolution and / or Release Characterization Transdermal Patches / Creams / […]