Preclinical Toxicology Testing Services

Preclinical toxicology and related safety studies are a pivotal part of the drug development life cycle, as they are needed to demonstrate that the test compound is safe, and at what doses, for administration to humans as part of clinical trials.

Start your safety and toxicology program with a strong strategy that anticipates issues and avoids costly delays.  

The Absorption Systems Difference

preclinical toxicologyEvery program is unique. Our team’s extensive experience with toxicology studies, and their preparedness for unexpected issues, ensure your study will produce regulatory compliant data within efficient turnaround.

  • Rapid IACUC Turnaround
  • AAALAC Accredited
  • OLAW Assured
  • GLP Compliant
  • In-House Veterinarians
  • Board and Certified Veterinary Pathologists
  • Small and Large Animal Models
  • Alternate Dose Routes
  • Clinical Bioanalysis

FREQUENTLY ASKED QUESTIONS

What species do you work with? 

  • Rats
  • Mice
  • Guinea Pigs
  • Rabbits
  • Dogs
  • Monkeys
  • Pigs, Minipigs
  • Sheep
  • Goats

What dose routes do you use?

  • Intravenous
  • Oral
  • Intraperitoneal
  • Sublingual
  • Buccal
  • Transdermal
  • Intraduodenal
  • Subcutaneous
  • Intracolonic
  • Intramuscular
  • Intratracheal
  • Ocular

What endpoints do you measure?

  • Toxicokinetics
    • LC-MS/MS platform
    • Biodistribution and TK parameters
  • Clinical Pathology
    • Hematology
    • Coagulation
    • Clinical Chemistry
  • Histopathology (local and systemic)

OUR CAPABILITIES

  • GLP Preclinical Studies
  • IND Enabling Studies
  • Dermal Toxicology
  • Ocular Toxicology
  • Device and Safety Testing
  • TK/PK Screening
  • DRF and MTD Studies
  • Subacute and Chronic Tox

TECHNOLOGIES AND METHODOLOGIES

We employ the latest technologies and methodologies in our toxicology testing.

  • Optical Coherence Tomography (OCT)
  • Electroretinography (ERG)
  • Fundus photography
  • Fluorescein Angiography
  • Intraocular Pressure (IOP)
  • Clinical Ophthalmic Examinations
    • Slit-lamp biomicroscopy & indirect ophthalmoscopy
    • Completed by a Board Certified Veterinary Ophthalmologist