In Vivo Ocular PK

The various compartment models used in pharmacokinetic research are used to explore the pharmacokinetic parameters. There are three major groups of transporters present at the ocular surface of the eye: transmembrane proteins, vasa-transporters, and transmuscular proteins. These transporters carry drugs from blood into the tissues and body organs. A number of pharmacological agents such as antibiotics and hormones are normally carried by transmembrane proteins.

Another group of transporters is the vasa-transporters, which are present at the middle part of the ocular surface where the blood supply passes through the cornea. This compartment is known as the enteric vasa-transporter because it carries drugs that pass through the oculomotor organ before reaching the eyes.

Absorption Systems offers in vivo ocular PK studies in large and small animals, including distribution among various ocular tissues.

Species

Rodent Minipig Rabbit Pig Dog Sheep

Dose Routes

Topical Punctal
Intracorneal Subconjunctival
Intravitreal Subtenon
Intracameral Suprachoroidal
Periocular Subretinal

Tissue Dissection

Lids Ciliary Body
Lacrimal Glands Trabecular Meshwork
Lacrimal Ducts Lens
Conjunctiva Vitreous Humor
Sclera Retina
Cornea Choroid
Aqueous Humor Optic Nerve
Iris Adnexa