In Vivo Ocular PK

The various compartment models used in pharmacokinetic research are used to explore the pharmacokinetic parameters. There are three major groups of transporters present at the ocular surface of the eye: transmembrane proteins, vasa-transporters, and transmuscular proteins. These transporters carry drugs from blood into the tissues and body organs. A number of pharmacological agents such as antibiotics and hormones are normally carried by transmembrane proteins.

Another group of transporters is the vasa-transporters, which are present at the middle part of the ocular surface where the blood supply passes through the cornea. This compartment is known as the enteric vasa-transporter because it carries drugs that pass through the oculomotor organ before reaching the eyes.

Absorption Systems offers in vivo ocular PK studies in large and small animals, including distribution among various ocular tissues.