Animal Disease Models
Animal Disease Model Services
Our in vivo pharmacology team is experienced with animal disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies. The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services in various therapeutic areas.
Models include oncology, cardiovascular and metabolic diseases, CNS/PNS diseases, inflammation and pain, ophthalmology, dermal diseases and medical devices.
Additional models available include hemostasis, leukocytopenia, intestine mobility, anemia, wounding/healing, renal failure, psoriasis and more.
Capabilities
Cardiovascular and Metabolic Models
- Obesity
- Type 1 diabetes
- Type 2 diabetes
- Cardiovascular diseases
- Organ damage diseases
- Respiratory disease
- Hyperuricemia
CNS/PNS Models
- Alzheimer’s disease
- Memory impairment
- Seizure
- Parkinson’s disease
- Depression / Anxiety / Schizophrenia
- Other neurodegenerative diseases
Dermal Disease Models
- in vitro dermal models
- ex vivo dermal models
- in vivo dermal models
Inflammation and Pain Models
- Acute and chronic pain models
- Immune disease models
- Non-immune inflammatory models
- Arthritis
- Visceral pain
- Surgery pain
- Neuropathic pain
- PDPK models
Medical Devices
- Cardiovascular Device Testing
- Ocular Device Testing
- Metabolic Disease Device Testing
Oncology Models
- Large cancer cell line and tissue bank
- CDX models and PDX models
- Syngeneic models with completed immune profile and SOC data
- Orthotopic imaging models (including intracranial models) using hundreds of human and murine cancer cell lines
- A platform to support radiation therapy
Ocular Disease Models
- Glaucoma
- Choroidal Neovascularization (CNV)
- Age-Related Macular Degeneration (AMD)
- Keratoconjunctivitis Sicca (KCS)
- Allergic conjunctivitis
- Anterior uveitis
- Infectious keratitis
- Neuroprotection
- Corneal wound healing
- Diabetic macular edema
