Corneal Wound Healing

Study Purpose

Evaluate the efficacy and safety of pharmaceuticals and drug-eluting devices designed to treat corneal epithelial defects

Type of Model

Evaluation of corneal wound healing drugs and devices


3-5 days post-surgery

Test System

New Zealand White rabbits,
Dutch Belted rabbits, pigs, sheep

Animals are prescreened
for ocular abnormalities


  • Evaluation of wound healing through clinical ophthalmic examinations using slit lamp biomicroscopy and flourescein staining
  • Digital photographs as necessary to benchmark healing process
  • Computer analysis of wound areas to quantitatively measure wound healing
  • Comparison of test article to currently approved therapeutics
  • Tissue harvest and histopathological analysis (optional)
  • Bioanalysis in target tissues (optional)

Model Description

  • Removal of nictitating membrane (optional)
  • Epithelial defect created in the center of the cornea with alcohol
  • Epithelium removed using Gill corneal knife or #15 Bard-Parker blade
  • Test article implanted by Absorption Systems- or Sponsor-provided surgeon
  • Clinical ophthalmic examinations at customized time points
  • Positive and negative control groups provide comparative data


  • More accurate classification of the test article’s treatment due to treated and untreated control groups
  • Consistent scoring of the eyes using FDA-required techniques
  • Advanced imaging equipment and expertise in-house to perform all evaluations on-site