Allergic Conjunctivitis Model
Study Purpose
Evaluate the efficacy and safety of pharmaceuticals designed to treat allergic conjunctivitis
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Type of Model Induction of allergic conjunctivitis |
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Time 1-14 days to establish model |
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Test System New Zealand White rabbit, guinea pig, rat, or mouse |
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Deliverables
- Ophthalmic exams using the McDonald-Shadduck scoring system
- Quantitative and qualitative in-life imaging techniques including slit-lamp biomicroscopy and ophthalmoscopy
- Comparison of the test article to currently approved therapeutics
- Tissue excision and histopathological analysis (optional)
- Bioanalysis of analyte concentrations in target tissues (optional)
Model Description
- Animal models are induced by one of the following methods:
- Parenteral dose of ovalbumin followed by repeated topical dosing of ovalbumin
- Topical application of compound 48/80
- Foot pad injection of ragweed pollen followed by repeated topical dosing of ragweed pollen
- Each model is assessed by the McDonald-Shadduck scoring system
- Following induction, subjects may be treated with a test compound and currently marketed therapeutic agent as a positive control
Benefits
- More accurate classification of the test article’s treatment due to treated and untreated control groups
- Consistent scoring of the eyes using FDA-required techniques
- Models are easily reproducible
- Advanced imaging equipment and expertise in-house to perform all evaluations on-site
