Ex Vivo Ocular Permeability

Our ex vivo model has been validated for correlation with in vivo ocular penetration potential:

  • Excised rabbit corneal and conjunctival tissue
  • Rank ordering of permeability for known ophthalmic agents
  • Metabolically active tissues for evaluating ester pro-drugs

Expertise in Ocular Models for Drug Permeability and Absorption
Absorption Systems has many years of experience performing in vitro tissue permeation studies across various drug absorption barriers. For ocular drug delivery, we offer ex vivo rabbit and human cornea and rabbit conjunctiva models. Using these models, we can rapidly determine the permeability of test compounds across each of these barriers and/or test different formulations.

Rabbit Conjunctiva used in Cornea / Conjunctiva Tissue Permeability studies
 
 
 
 
 
 
 
 
 
 
Rabbit conjunctiva image obtained by scanning electron microscope
 
Rabbit Cornea
 
 
 
 
 
 
 
 
 
 
Rabbit cornea image obtained by scanning electron microscope

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