OCULAR

Optimized Ocular Models Focused on Improving Outcomes

Our nonclinical ocular models include in vivo and ex vivo options for implants, small and large molecules. Absorption Systems provides specialized tissue-based ADME ocular models that can provide a comprehensive study from design to testing to endpoint analysis using conditions optimized for your compound.

All animal studies are performed in our 50,000 sq. ft. AAALAC-accredited, GLP-compliant and NIH-assured vivarium located in San Diego, CA. We have experience with species such as rabbit, pig, dog, and sheep plus disease models including glaucoma, AMD, KCS, CNV and more. Learn more about our ophthalmic research programs below.

Services

• Ocular In Vivo Capabilities

  State-of-the-art equipment to capture data and images: Direct & Indirect Ophthalmoscopy Slit-Lamp Biomicroscopy Optical Coherence Tomography (OCT) – Posterior Segment: 30° Lens, 55° Lens – Anterior Segment: Cornea Lens Fundus […]

• Ocular In Vivo Disease Models

  Wet AMD Choroidal Neovascularization (CNV) Glaucoma Corneal Wound Healing Keratoconjunctivitis Sicca (KCS) Uveitis Allergic Conjunctivitis Diabetic Retinopathy Bacterial Keratitis New Model Development

• Ex Vivo Ocular Permeability

  Our ex vivo model has been validated for correlation with in vivo ocular penetration potential: Excised rabbit corneal and conjunctival tissue Rank ordering of permeability for known ophthalmic agents Metabolically active tissues for evaluating […]

• In Vivo Ocular PK

  Absorption Systems offers in vivo ocular PK studies in large and small animals, including distribution among various ocular tissues. Species Rodent Minipig Rabbit Pig Dog Sheep Dose Routes Topical Punctal Intracorneal Subconjunctival […]

• Ocular Toxicology

  From candidate selection through IND submission  Ocular safety and tox programs require a specific skill set and experience in ophthalmic research to guide successful program execution.  Absorption Systems brings over […]

• Ocular Devices

  Our experts have worked with the leading makers of ocular devices. We can guide you through model selection, implantation procedures, PK analysis (if applicable), and histopathology. Our experience spans acute […]

• Cell and Gene Therapy Ocular Services

  Optimized Ocular Models Focused on Improving Outcomes Absorption Systems offers specialized preclinical in vivo ocular models for cell and gene therapy products. Wild type, genetically modified, immunodeficient, and disease-induced models are […]

• Bioanalytical

  Screening to Fully Validated GLP Bioanalysis Our bioanalytical services expertise provides quantitative measurements on a range of active drugs, from small molecules to peptides, as well as metabolites. We can perform analysis […]