OCULAR TESTING

Optimized Ocular Models Focused on Improving Outcomes

Our nonclinical ocular models include in vivo and ex vivo options for implants, small and large molecules. Absorption Systems provides specialized tissue-based ADME ocular models that can provide a comprehensive study from design to testing to endpoint analysis using conditions optimized for your compound.

All animal studies are performed in our 50,000 sq. ft. AAALAC-accredited, GLP-compliant and NIH-assured vivarium located in San Diego, CA. We have experience with species such as rabbit, pig, dog, and sheep plus disease models including glaucoma, AMD, KCS, CNV and more. Learn more about our ophthalmic research programs below.

Our experts have worked with the leading makers of ocular devices. We can guide you through model selection, implantation procedures, PK analysis (if applicable), and histopathology. Our experience spans acute and chronic studies evaluating:

• ISO Certified
• Biocompatibility Testing
• Contact Lenses
• Corneal Inlays
• Intraocular Lens Implants
• Anterior and Posterior Drug-Eluting Devices

• Ocular In Vivo Capabilities

  State-of-the-art equipment to capture data and images: Direct & Indirect Ophthalmoscopy Slit-Lamp Biomicroscopy Optical Coherence Tomography (OCT) – Posterior Segment: 30° Lens, 55° Lens – Anterior Segment: Cornea Lens Fundus […]

• Surgical Models for Ocular and Cardiovascular Diseases

  Due to our wide breadth of surgical experience and intimate knowledge of animal anatomy, Absorption Systems is able to create and induce a multitude of clinically relevant disease states in […]

• Ex Vivo Ocular Permeability

  Our ex vivo model has been validated for correlation with in vivo ocular penetration potential: Excised rabbit corneal and conjunctival tissue Rank ordering of permeability for known ophthalmic agents Metabolically active tissues for evaluating […]

• Cell and Gene Therapy Ocular Services

  Optimized Ocular Models Focused on Improving Outcomes Absorption Systems offers specialized preclinical in vivo ocular models for cell and gene therapy products. Wild type, genetically modified, immunodeficient, and disease-induced models are […]

• Preclinical Pharmacokinetics Testing Services

  Navigating regulatory requirements for bioanalytical testing can be challenging and time-consuming. Absorption Systems’ bioanalytical experts will provide you with complete study support, from formulation to PK parameters.  With the convenience […]

• Preclinical Toxicology Testing Services

  Preclinical toxicology and related safety studies are a pivotal part of the drug development life cycle, as they are needed to demonstrate that the test compound is safe, and at […]