Ocular Safety Assessment

Ocular Safety Assessment Services

Pharmaron’s ocular toxicology studies can be conducted under GLP (histopathology and clinical pathology)  or non-GLP conditions. Our team has experience using small molecules, biologics, cell therapy, gene therapy, implants and transplants and works with rodents and non-rodents. We have on-site ACVO board-certified veterinary ophthalmologists to oversee all studies.

Ocular Disease Models

  • Glaucoma
  • Choroidal Neovascularization (CNV)
  • Age-Related Macular Degeneration (AMD)
  • Keratoconjunctivitis Sicca (KCS)
  • Allergic conjunctivitis
  • Anterior uveitis
  • Infectious keratitis
  • Neuroprotection
  • Corneal wound healing
  • Diabetic macular edema

Data and Image Capturing Capabilities

  • Slit-lamp biomicroscopy with photography
  • Pneumatonometery (IOP Measurement)
  • Optical coherence tomography
  • Surgical/operating microscope – videography
  • Direct/indirect ophthalmoscopy
  • Phacoemulsion 
  • Laser
  • Specular microscopy
  • Color fundus photography
  • Fluorescein angiography
  • Electroretinography
  • Optokinetic response
  • Vitrectomy

Dose Routes

  • Topical 
  • Punctal
  • Intracorneal
  • Intravitreal
  • Intracameral
  • Periocular
  • Subconjunctival
  • Subtenon
  • Suprachoroidal
  • Subretinal
eye diagram

Tissue Dissection

  • Lids
  • Lacrimal glands
  • Lacrimal ducts
  • Conjunctiva
  • Sclera
  • Cornea
  • Aqueous humor
  • Iris
  • Ciliary body
  • Trabecular meshwork
  • Lens
  • Vitreous humor
  • Retina
  • Choroid
  • Optic nerve
  • Adnexa