OCULAR

Optimized Ocular Models Focused on Improving Outcomes

Our nonclinical ocular models include in vivo and ex vivo options for implants, small and large molecules. Absorption Systems provides specialized tissue-based ADME ocular models that can provide a comprehensive study from design to testing to endpoint analysis using conditions optimized for your compound.

All animal studies are performed in our 50,000 sq. ft. AAALAC-accredited, GLP-compliant and NIH-assured vivarium located in San Diego, CA. We have experience with species such as rabbit, pig, dog, and sheep plus disease models including glaucoma, AMD, KCS, CNV and more. Learn more about our ophthalmic research programs below.

 

Our experts have worked with the leading makers of ocular devices. We can guide you through model selection, implantation procedures, PK analysis (if applicable), and histopathology. Our experience spans acute and chronic studies evaluating:

• ISO Certified
• Biocompatibility Testing
• Contact Lenses
• Corneal Inlays
• Intraocular Lens Implants
• Anterior and Posterior Drug-Eluting Devices

• Ocular In Vivo Capabilities

  State-of-the-art equipment to capture data and images: Direct & Indirect Ophthalmoscopy Slit-Lamp Biomicroscopy Optical Coherence Tomography (OCT) – Posterior Segment: 30° Lens, 55° Lens – Anterior Segment: Cornea Lens Fundus […]

• Ocular/Vascular Disease and Surgical Models

  Due to our wide breadth of surgical experience and intimate knowledge of animal anatomy, Absorption Systems is able to create and induce a multitude of clinically relevant disease states in […]

• Ex Vivo Ocular Permeability

  Our ex vivo model has been validated for correlation with in vivo ocular penetration potential: Excised rabbit corneal and conjunctival tissue Rank ordering of permeability for known ophthalmic agents Metabolically active tissues for evaluating […]

• In Vivo Ocular PK

  Absorption Systems offers in vivo ocular PK studies in large and small animals, including distribution among various ocular tissues. Species Rodent Minipig Rabbit Pig Dog Sheep Dose Routes Topical Punctal Intracorneal Subconjunctival […]

• Cell and Gene Therapy Ocular Services

  Optimized Ocular Models Focused on Improving Outcomes Absorption Systems offers specialized preclinical in vivo ocular models for cell and gene therapy products. Wild type, genetically modified, immunodeficient, and disease-induced models are […]

• Tolerability / Toxicology

  Start your safety and tox program with a strong strategy that anticipates issues and avoids costly delays.  From pharmacokinetics through safety/tox assessments, Absorption Systems has the experience and accredited resources […]

• Ocular Device Testing Facility

  Ophthalmic Equipment Ophthalmic Instruments Zeiss Operating Microscope OPMI6CFCXY Orion Television (for projection purposes) from Zeiss Microscope Toshiba DVD, Sony Video Camera (for projection purposes) Hitachi Video Camera (for projection purposes) […]