Developmental and Reproductive Toxicology (DART) Services

Pharmaron provides developmental and reproductive toxicology (DART) services to evaluate agents for the life sciences industry. The DART team offers a comprehensive set of studies to evaluate developmental and reproductive toxic potential. They also offer customized study designs, such as ePPND.

DART Study Designs:

Fertility and early embryonic development
Embryo-fetal development
Perinatal and postnatal development
Prenatal developmental toxicity
One-Generation reproduction toxicity
Two-Generation reproduction toxicity
Reproduction/developmental toxicity screen
Extended one-generation reproductive toxicity

Capabilities

General Toxicology

Safety Pharmacology

Genetic Toxicology

Developmental and Reproductive Toxicology

Specialty Safety Assessment

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Segment I Study Designs

Maturation of gametes
Mating behavior
Fertility
Pre- and post-implantation development
Sperm analysis

Segment II Study Designs

Maternal toxicity
Embryotoxicity
Fetotoxicity
Teratogenicity (fetal external evaluation, fetal soft tissue evaluation, fetal skeletal evaluation)

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Segment III Study Designs

Development landmarks
Sensory functions
Motor activity
Learning and memory
Reproductive function

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Pharmaron’s experienced team evaluates the safety of new drug candidates from general toxicology, safety pharmacology, genetic toxicology, DART to immunotoxicity and immunogenicity in support of our partner’s IND and NDA submissions worldwide.

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Learn more about Pharmaron’s integrated drug discovery and development services

Pharmaron provides a complete integrated platform from drug discovery to proof of concept (“POC”). Our industry knowledge, strong execution tactics and end-to-end solutions shorten the drug discovery and development cycle.