IN VIVO TESTING SERVICES

Absorption Systems offers a wide range of support for in vivo animal studies for research and clinical applications.

Working as an extension of your laboratory, we offer flexibility in the planning of your studies as well as progress reports at each phase. 

Absorption Systems is AAALAC accredited and USDA registered and maintains an internal Institutional Animal Care and Use Committee (IACUC) in accordance with USDA and HHS regulations and guidelines.

The Absorption Systems Difference

We value a close relationship and communication with our customers. You’ll always have a dedicated team who’ll answer your questions within 24 hours and you will know in real-time what is going on with your study.

Our experience includes: 

• Prepare and approve IACUC protocols in accordance with USDA and HHS regulations and guidelines
• Development of vaccine immunization schedules, dosing, and adjuvant screening
• Dose tolerability and immunogenicity evaluation
• Pharmacokinetics (PK) and pharmacodynamics (PD) rodent studies
• Gene therapy applications and AAV testing
• Dermal and metabolism (i.e. DIO) model
• Injection site reaction (ISR) studies
• Xenograft tumor models
• Transgenic breeding programs
• Biodistribution studies using Li-Cor fluorescent imaging system for tissue section imaging (including full body image)
• Bioanalytical support for dose-ranging and bioavailability studies
• Tissue homogenization, protein, and nucleic acids extraction

Diagnostic Analysis of Samples:

• Complete chemistry analysis: albumin, ALT, BUN, calcium
• Cholesterol, creatinine, glucose, protein, uric acid, etc.
• Complete clinical analysis: blood gases, acid-base balance, pH, electrolytes, etc.

• In Vivo Ocular PK

  The various compartment models used in pharmacokinetic research are used to explore the pharmacokinetic parameters. There are three major groups of transporters present at the ocular surface of the eye: […]

• Ocular In Vivo Capabilities

  State-of-the-art equipment to capture data and images: Direct & Indirect Ophthalmoscopy Slit-Lamp Biomicroscopy Optical Coherence Tomography (OCT) – Posterior Segment: 30° Lens, 55° Lens – Anterior Segment: Cornea Lens Fundus […]

• Biologics & Gene Therapy 𝘐𝘯 𝘝𝘪𝘷𝘰 Services

  In vivo studies using preclinical models are critical throughout biologic development, from early PK/PD studies to GLP-approved safety and efficacy programs. Maximising insight requires expertise in the models, surgical techniques […]

• Bioassay Testing Services

  Absorption Systems provides the Pharmaceutical, Biotechnology and Academic communities a comprehensive range of analytical lab services in support of basic research and development as well as for clinical studies. We […]

• Cell and Gene Therapy Ocular Services

  Optimized Ocular Models Focused on Improving Outcomes Absorption Systems offers specialized preclinical in vivo ocular models for cell and gene therapy products. Wild type, genetically modified, immunodeficient, and disease-induced models are […]

• Metabolic disease

  Metabolic disease or syndrome (MetS) is a multifactorial condition combining diabetes, high blood pressure and obesity. MetS has emerged as a significant challenge to public health and biomedical research. Preclinical […]

• Dose Ranging Studies

  While a true dose-ranging study is a clinical trial, Absorption Systems offers in vivo dose ranging studies where titerable doses of a test article or compound are tested against each other […]

• Ocular Devices

  Ocular devices are a growing market in both traditional pharmaceuticals and the medical device sector. Combining reliable preclinical disease models with multimodal imaging and histology can progress your pipeline forward. […]