IN VITRO

  • Transporters

    Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]

  • Permeability

    Cell-Based Different cell lines (e.g., Caco-2 clone C2BBe1, MDR1-MDCK, MDCK, BCRP-MDCK) are used as in vitro models for different purposes. Caco-2 cell monolayers predict not only intestinal absorption but also drug-drug […]

  • Metabolism

    Metabolism is the enzymatic modification of drugs and other xenobiotics, usually to increase clearance. It is a determinant of oral bioavailability, clearance, and half-life in vivo. Metabolism occurs predominantly in the […]

  • Physicochemical Properties and Dose Selection

    Solubility Assessment (bio-buffers and formulation excipients) Dissolution Testing Chemical Stability Dose Vehicle Development & Evaluation: Excipient Selection API – Compatibility Vehicle – Suitability Stability (dose vehicle) Artificial Fluids Interactions Simulated […]

  • In Vitro Dissolution Absorption System (IDAS)

    Biopharmaceutics dissolution with better in vivo correlation The In Vitro Dissolution Absorption System (IDASTM) combines traditional dissolution testing with a means to determine and quantify interactions with a bio-relevant membrane. IDAS provides […]

  • In Vitro Release Testing (IVRT)

    Measurement of drug release from complex dosage forms intended for ophthalmic and topical applications is fundamental to drug product development and product equivalence testing.  Inherent to the concepts of quality […]

  • In Vitro Permeation Testing (IVPT)

    In Vitro permeation testing (IVPT) studies across biological membranes for formulations that are applied to the skin or in the eye are vital to guide product development and establish product […]