Trends in Dermal Delivery

Drug delivery by the dermal route is increasingly popular for a variety of reasons, including:

  • Opportunity to extend pipelines by modifying formulation/route of administration
  • Emergence of topical generics and cosmeceuticals
  • Consumer benefits, such as improving convenience and flexibility for self-administration, home care, patient and caregiver compliance
  • Localized, efficient drug delivery
  • Enhanced bioavailability (bypass first-pass metabolism)


An integrated and dynamic experimental approach, incorporating in vitro, ex vivo, and in vivo non-clinical models can be used to evaluate dermal delivery (tissue-based and pharmacokinetic models), compare and optimize formulations, minimize DoE runs, and guide critical investment decisions.

Absorption Systems’ unique portfolio of dermal models provides a comprehensive package of predictive testing. We employ a rational and multi-pronged approach which relies on well-validated, nonclinical models to bypass clinical studies and/or enhance quality by design (QbD).  This approach allows you to advance your dermatological innovations with increased accuracy and confidence.

Absorption Systems can excel your dermatological advancements with our commitment to accuracy and innovation in preclinical testing and research.


Preclinical Dermal Models

In Vitro Dermal Models

  • In Vitro Release Testing (IVRT)
  • Topical Formulation
  • Stability

In Vitro approaches enable early identification of favorable compound properties in a cost effective setting

Ex Vivo Dermal Models

  • In Vitro Permeation Testing (IVPT)
  • Ex Vivo Dermal Permeability
  • Dermal Permeability Study
  • Penetration and Accumulation
  • Barrier Integrity Measurements

Ex Vivo studies allow the determination of drug permeation across different layers of the skin (IVPT)

In Vivo Dermal Models

  • Dermal PK & Irritation
  • Dermal Pharmacokinetics Study
  • Dermal Irritation Study
  • Dermal Efficacy Models
  • Wound Healing
  • Mouse IMQ Model of Psoriasis

In Vivo studies allow confirmation of results when all physiological factors are present


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Tell us about your dermal studies and learn how we can help