Trends in Dermal Drug Delivery

Drug delivery by the dermal route is increasingly popular for a variety of reasons, including:

• Opportunity to extend pipelines by modifying formulation/route of administration
• Emergence of topical generics and cosmeceuticals
• Consumer benefits, such as improving convenience and flexibility for self-administration, home care, patient and caregiver compliance
• Localized, efficient drug delivery
• Enhanced bioavailability (bypass first-pass metabolism)

An integrated and dynamic experimental approach, incorporating in vitro, ex vivo, and in vivo non-clinical models can be used to evaluate dermal delivery (tissue-based and pharmacokinetic models), compare and optimize formulations, minimize DoE runs, and guide critical investment decisions.

The Absorption Systems Difference

Absorption Systems’ unique portfolio of dermal models provides a comprehensive package of predictive testing. We employ a rational and multi-pronged approach that relies on well-validated, nonclinical models to bypass clinical studies and/or enhance quality by design (QbD).  This approach allows you to advance your dermatological innovations with increased accuracy and confidence.

Absorption Systems can accelerate your dermatological advancements with our commitment to accuracy and innovation in preclinical testing and research.


Preclinical Dermal Models

In Vitro Dermal Models

Ex Vivo Dermal Models

In Vivo Dermal Models

  • Dermal PK & Irritation
  • Dermal Pharmacokinetics Study
  • Dermal Irritation Study
  • Dermal Efficacy Models
  • Wound Healing
  • Mouse IMQ Model of Psoriasis
  • In Vitro Release Testing (IVRT)

    Measurement of drug release from complex dosage forms intended for ophthalmic and topical applications is fundamental to drug product development and product equivalence testing.  Inherent to the concepts of quality […]

  • In Vitro Permeation Testing (IVPT)

    In Vitro permeation testing (IVPT) studies across biological membranes for formulations that are applied to the skin or in the eye are vital to guide product development and establish product […]

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