Preclinical Pharmacokinetics Testing Services

  • Complete study support from formulation to PK parameters
  • Rapid turnaround to support drug discovery
  • Experienced team with more than 30 years supporting DMPK
  • End-to-end in-life with bioanalytical support

FREQUENTLY ASKED QUESTIONS

What species do you work with?

  • Dog
  • Guinea Pig
  • Mouse
  • Porcine
  • Rabbit
  • Rat

Do you work with specialized animal models?

What dose routes do you use?

  • Routine: IV, PO, SC, IM, IP
  • Standard: Ophthalmic, Dermal, Intranasal, Intraoral, Buccal
  • Specialty: GI (ID, IJ, IC), IT, Intra-articular

What toxicity/tolerability do you measure?

CAPABILITIES

  • Test Articles: Small and Large Molecules, Cell & Gene Therapy
  • Matrices: Plasma, Tissue, Urine, Feces, Bile, Lymph, CSF
  • Sample Analysis and Reporting: Measured concentrations and PK parameters
  • 72-hour turnaround time for plasma sample BA
  • Biofluid Sampling: Jugular vein, Portal vein, bile, cannula, urine, feces, lymph cannula (other suitable veins), CSF, Synovial Fluid, and more

TECHNOLOGIES AND METHODOLOGIES

  • Bertin Precellys® 24 Tissue Homogenizer
  • LC-HRAMS
  • LTQ Orbitrap
  • VersaMaxTM Microplate Readers
  • Waters ACQUITY UPLC Systems
  • Waters Xevo TQ Systems

Visit our online store to view protocols or purchase Express PK studies. Request a custom study design.