Preclinical Pharmacokinetics Testing Services

The Absorption Systems Difference

We take a truly end-to-end approach to preclinical PK studies. From formulation to PK parameters, our experienced team have been supporting DMPK for over 30 years. Our combined expertise in both in vitro and in vivo preclinical PK studies mean we know the right questions to ask and how to answer them, across model systems. We also recognise the time-sensitive nature of these studies and offer rapid turnaround times that support drug discovery timelines. 


What species do you work with?

We work with a range of preclinical models that enables us to select the most suitable model for a particular dose route, treatment regimen or endpoint. Our models include:

  • Dog
  • Guinea Pig
  • Mouse
  • Porcine
  • Rabbit
  • Rat


Do you work with specialized animal models?


What dose routes do you use?

Our scientists are experienced in a range of dosage routes, including more specialised routes. We have a selection of different preclinical models to match suitable routes of administration to:

  • Routine: IV, PO, SC, IM, IP
  • Standard: Ophthalmic, Dermal, Intranasal, Intraoral, Buccal
  • Specialty: GI (ID, IJ, IC), IT, Intra-articular


What toxicity/tolerability do you measure?

A summary of our toxicology and tolerability study details is given below:

Standard species


Toxicity & tolerability

Standard endpoints
  • Rodent
  • Rabbit
  • Dog
  • Minipig
  • 7, 14, 28 and 90 day
  • Chronic (6-9+ months)
  • Clinical observations
  • Body weights
  • Food consumption
  • TK analysis
  • Histopathology
  • Clinical pathology


Adaptable assays that get you the information you need:

  • Test Articles: Small and Large Molecules, Cell & Gene Therapy
  • Matrices: Plasma, Tissue, Urine, Feces, Bile, Lymph, CSF
  • Sample Analysis and Reporting: Measured concentrations and PK parameters
  • 72-hour turnaround time for plasma sample BA
  • Biofluid Sampling: Jugular vein, Portal vein, bile, cannula, urine, feces, lymph cannula (other suitable veins), CSF, Synovial Fluid, and more


State-of-the-art assays analysed with cutting edge technology:

  • Bertin Precellys® 24 Tissue Homogenizer
  • LTQ Orbitrap
  • VersaMaxTM Microplate Readers
  • Waters ACQUITY UPLC Systems
  • Waters Xevo TQ Systems

Visit our online store to view protocols or purchase Express PK studies. Request a custom study design.