Ocular Toxicology
From candidate selection through IND submission
Ocular safety and tox programs require a specific skill set and experience in ophthalmic research to guide successful program execution. Absorption Systems brings over 35 years of focused experience and features state-of-the-art ocular diagnostic equipment to help develop your compound from candidate selection through IND submission with confidence. Our dedicated ocular team supports a wide selection of preclinical species and dose routes and has experience with a variety of new treatment types to tailor your ocular program for regulatory submission.
Diagnostics
- Optical Coherence Tomography (OCT)
- Electroretinography (ERG)
- Fundus photography
- Fluorescein Angiography
- Intraocular Pressure (IOP)
- Clinical Ophthalmic Examinations
– Slit-lamp biomicroscopy & indirect ophthalmoscopy
– Completed by a Board Certified Veterinary Ophthalmologist
End Points
- Toxicokinetics
– LC-MS/MS platform
– Biodistribution and TK parameters - Clinical Pathology
– Hematology
– Coagulation
– Clinical Chemistry - Histopathology (local and systemic)
| Species | Dose Routes | Capabilities |
|---|---|---|
| Mouse | Topical | Small & Large Molecule |
| Rat | Intravitreal | Biologics |
| Rabbit | Sub-Conjunctival | Stem Cells |
| Minipig | Sub-Retinal | Devices |
| Dog | Intracameral | Cell & Gene Therapy |
Benefits of Working with Absorption Systems
- Rapid IACUC Turnaround
- AAALAC Accredited
- OLAW Assured
- GLP Compliant
- In-House Veterinarians
- Board Certified Veterinary Pathologists & Ophthalmologists
- Small and Large Animal Models
- Alternate Dose Routes
- Clinical Bioanalysis
