Ocular Toxicology

From candidate selection through IND submission 

Ocular safety and tox programs require a specific skill set and experience in ophthalmic research to guide successful program execution.  Absorption Systems brings over 35 years of focused experience and features state-of-the-art ocular diagnostic equipment to help develop your compound from candidate selection through IND submission with confidence.  Our dedicated ocular team supports a wide selection of preclinical species and dose routes and has experience with a variety of new treatment types to tailor your ocular program for regulatory submission.


  • Optical Coherence Tomography (OCT)
  • Electroretinography (ERG)
  • Fundus photography
  • Fluorescein Angiography
  • Intraocular Pressure (IOP)
  • Clinical Ophthalmic Examinations
    – Slit-lamp biomicroscopy & indirect ophthalmoscopy
    – Completed by a Board Certified Veterinary Ophthalmologist

End Points

  • Toxicokinetics
    – LC-MS/MS platform
    – Biodistribution and TK parameters
  • Clinical Pathology
    – Hematology
    – Coagulation
    – Clinical Chemistry
  • Histopathology (local and systemic)
Species Dose Routes Capabilities
Mouse Topical Small & Large Molecule
Rat Intravitreal Biologics
Rabbit Sub-Conjunctival Stem Cells
Minipig Sub-Retinal Devices
Dog Intracameral Cell & Gene Therapy
ocular toxicology


Benefits of Working with Absorption Systems

  • Rapid IACUC Turnaround
  • AAALAC Accredited
  • OLAW Assured
  • GLP Compliant
  • In-House Veterinarians
  • Board Certified Veterinary Pathologists & Ophthalmologists
  • Small and Large Animal Models
  • Alternate Dose Routes
  • Clinical Bioanalysis