Optimized Ocular Models Focused on Improving Outcomes Our nonlinical ocular models include in vivo and ex vivo options for implants, small and large molecules. Absorption Systems provides specialized tissue-based ADME ocular models that can provide a comprehensive study from design to testing to endpoint analysis using conditions optimized for your compound.

All animal studies are performed in our 50,000 sq. ft. AAALAC-accredited, GLP-compliant and NIH-assured vivarium located in San Diego, CA. We have experience with species such as rabbit, pig, dog, and sheep plus disease models including glaucoma, AMD, KCS, CNV and more. Learn more about our ophthalmic research programs below.

Services
In Vivo Capabilities Utilizing state-of-the-art equipment to capture data and images for ocular studies
In Vivo Disease Models Evaluate your compound’s efficacy in disorders affecting both the front and back of the eye
Ex Vivo Permeability Ex Vivo models validated for correlation with the in vivo ocular penetration potential
In Vivo Ocular PK Studies performed in small and large animal, distribution among various ocular tissues
Safety & Toxicology From candidate selection through IND submission with our comprehensive portfolio of preclinical PK and tox services
Ocular Devices Guided assistance through model selection, implantation procedures, PK analysis and histopathology
Bioanalytical LC-MS/MS for small molecules, ELISA for large molecules, sensitive optimized assays
Cell & Gene Therapy Delivery of stem cells, advanced cell viability assessment, IHC, qPCR, ELISA and in vivo modalities
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Species & Dose Routes
Diagnostics & Capabilities
Ocular Resources
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preclinical ophthalmic