WHITE PAPER: Lysosomal Trapping, Cytotoxicity, and Cellular Partitioning of Test Compounds using Hepatocytes

Lysosomes are a motley collection of membrane-bound cellular organelles that play a variety of roles in cellular degradation, metabolism, cellular signaling, and programmed cell death. Lysosomal sequestration can be a useful tool in interpreting the pharmacokinetics and safety of candidate therapeutic compounds. This whitepaper discusses the significance of lysosomal trapping in physiologically based pharmacokinetic models.