Topical or Subcutaneous Administration of AKB-9778, a Tie2 Activator, Reduces IOP in NZW Rabbits

Topical or Subcutaneous Administration of AKB-9778, a Tie2 Activator, Reduces IOP in NZW Rabbits
Gum, Glenwood G.; Janusz, John; Soldo, Brandi; Walker, Brian; Buch, Akshay; Pakola, Steve; Peters, Kevin G.
Absorption Systems, San Diego, California; Aerpio Pharmaceuticals, Cincinnati, Ohio

This poster was presented at The Association for Research in Vision and Ophthalmology Annual Meeting April 2018
Abstract
Tie2 dysfunction in the conventional outflow pathway has been implicated in glaucoma (Kim et al, JCI 2017;127:3877-96). AKB-9778 is a small molecule inhibitor of VE-PTP, the most critical negative regulator of Tie2. The purpose of the study was to test the tolerability and effect on intraocular pressure (IOP) of repeat administration of AKB-9778 in normotensive New Zealand White(NZW) rabbits.

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