Transporters

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In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs

In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs Yuri Bukhtiyarov, Jibin Li, Nicole Spivey, Svitlana Silchenko, [...]

Gut Reactions: An ADME-Centric View of the Gut Microbiome

Did you know that, although we’re 100% human at birth, by adulthood we’re 90% bacteria?  That’s because we harbor ten times more bacterial cells in our microbiome [...]

2019-09-12T15:15:32-05:00September 9, 2019|Categories: AbsorbThis Blog|Tags: , |

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition

Introduction P-glycoprotein (P-gp) is a drug transporter recommended by regulatory agencies for in-vitro and in-vivo DDI evaluation. Due to high inter-laboratory variability in in-vitro P-gp data, regulators [...]

2019-07-18T15:00:45-05:00July 18, 2019|Categories: AbsorbThis Blog, Drug Transporters|Tags: , , |

Metformin Clinical DDI Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision

Introduction Metformin is an orally administered drug prescribed for the treatment of Type 2 diabetes. It is known to decrease hepatic glucose production, by inhibiting gluconeogenesis, and [...]