OAT Drug Transporter

Clinically Relevant Probe Substrates and Inhibitors

OAT1
Substrates Inhibitors
adefovir, captopril, furosemide, lamivudine, methotrexate*, para-aminohippurate (PAH)*, oseltamivir, tenofovir, zalcitabine, zidovudine probenecid‡
OAT3
Substrates Inhibitors
Acyclovir, bumetanide, ciprofloxacin, famotidine, furosemide*, methotrexate*, zidovudine, penicillin G, pravastatin, rosuvastatin, sitagliptin probenecid‡, cimetidine, diclofenac
*Probe substrate validated by Absorption Systems
‡Inhibitor validated by Absorption Systems