Increased Expression of IGFBP2 Induces RPE and Photoreceptor Degeneration at Senescence
Sandeep Kumar; Amrita Fnu; Mackenzie Parker; Glenwood Gum; Vatsala Naageshwaran; Yingbin Fu
Absorption Systems, San Diego, CA; Cullen Eye Institute, Houston, TX
This poster was presented at ARVO, April 2019
Insulin like growth factor binding protein 2 (IGFBP2) belongs to a highly conserved family of insulin-like growth factor (IGF) binding proteins that modulate IGF-1 actions. IGFBP2 locus 2q33-q34 is linked to glaucoma related traits. In addition, elevated levels of IGFBP2 have been detected in the vitreous and aqueous humor of neovascular eye diseases. Here, we performed in vivo imaging, histological and functional analysis of a transgenic mouse line (TgIGFBP2) overexpressing human IGFBP2.