Efficacy and Safety Assessment of Topical Therapy in a Mouse Model of Inflammatory Acne
S.E. Nikoulina, S. Smith, J. Leong, C. Smith, S. Womble, V. Naageshwaran,
Absorption Systems , San Diego, California
This poster was presented at the Society of Toxicology Annual Meeting & Tox Expo March 2018
In the treatment of acne vulgaris the target organism is primarily Propionibacterium acnes, a Gram-positive bacteria found in the pilosebaceous glands of human skin. Presence of these pathogens is associated with inflammatory lesions in the skin and related to direct stimulation of the innate immune response. Development of efficacious and safe topical therapies for acne is dependent on translatable preclinical models that can reflect the inflammatory response of human acne and incorporate physiological parameters of the skin barrier. This project was undertaken to develop and establish an inflammatory model of acne in nude mice. Since the endpoint is to determine functional outcome and histological changes, a living model was established using two mouse strains with varying immune responses; the hairless SKH1 mice (euthymic and immunocompetent) and BABL/c-nu mice that lack a thymus and unable to produce T cells and therefore are immunodeficient.
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