Dermal Toxicology Services

In Vivo dermal studies evaluate the pharmacokinetics, toxicity, and/or efficacy of test compounds and formulations on the skin.  Absorption Systems’ tailored approach to preclinical dermal testing will take your program from candidate selection through IND submission. Our models assess dermal PK, irritation, toxicology, and efficacy. Studies are available in small and large animals, on intact or compromised skin, and in healthy or diseased animal models.

Species: Mouse, Rat, Rabbit, Minipig (Yucatan, Gottingen), Pig (Yorkshire)

Test Articles: Drugs (Patches, Creams, Gels, Ointments, Liquids, Lotions), Devices, Grafts, Stems Cells, Dressings/Structures

Dermal Toxicology:

  • Repeat Administration
  • Draize Scoring
  • Toxicokinetics
    • LC-MS/MS Platform
    • Biodistribution and TK Parameters
  • Clinical Pathology
    • Hematology
    • Coagulation
    • Clinical Chemistry
  • Histopathology (Local & Systemic)

Dermal Irritation: Evaluate the irritation effects after single or repeat dermal administration.
Species: Rabbit, Guinea Pig
Digital Photographs, Draize Scoring

Dermal Efficacy: