Study Purpose

from formulations across synthetic
membranes in Franz cells

Evaluate the local and systemic distribution of test articles after dermal application

Type of Model
Dermal PK
14-28 days
Test System


  • Concentration of test article accumulated at the dose site
  • Concentration of test article in systemic circulation
  • PK parameters using non-compartmental analysis: AUC, Cmax, Tmax, and half-life
  • Draize scoring (erythema and edema) to evaluate dermal irritation at the dose site

Model Description

  • Intact or abraded skin
  • Dosing forms: gel, cream, patch, liquid
  • Dosing and bandaging procedures are customized for each test article and animal model
  • Diabetic, wounded, and infectious models available
  • Comparison to intravenous dose to determine bioavailability (optional)


  • On-site scientists with professional experience with small and large animals
  • Dedicated operations manager to facilitate study conduct and minimize turnaround time
  • In-house bioanalytical and formulation services
  • Consultative assistance in animal model selection