Characterization of angiographic features and validation of a chronic wet AMD rabbit model induced by DL-AAA
Vatsala Naageshwaran, John Quach, Nicholas Cook, Kayla Martinez, Ashley Renteria, Jenny Walters, Andrew Zhao, Jeffrey Parsons, Dinh Albright, Christian J. Hissom, Matthew Lyulkin, Scott Womble, Nurith Amitai-Crawford, Glenwood Gum, Sandeep Kumar
Ophthalmology Department, Absorption Systems, San Diego, CA

This poster was presented at ARVO, April 2019

DL-2-aminoadipic acid (DL-AAA), a retinal glial (Müller) cell toxin, has been shown to induce retinal neovascularization (RNV) and chronic retinal vasculature leakage after intravitreal (IVT) administration. Here, we have extensively characterized DL-AAA induced angiographic features in Dutch Belted (DB) rabbit eyes and established suitability of this model to test anti-neovascular therapies.