Drug Discovery and Development

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Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation

Perspectives From the International Transporter Consortium Introduction Transporter studies are performed at various stages of drug development ‒ discovery to first-in-human (FIH) phase (in-vitro substrate and inhibition [...]

2019-08-20T12:39:25-04:00August 20, 2019|Categories: AbsorbThis Blog, Drug Transporters|

Monitoring Oral Solid Dosage Forms Quality by NIR Spectroscopy and IDAS2

Monitoring Oral Solid Dosage Forms Quality by NIR Spectroscopy and IDAS2 Johayra Simithy1, Carlos Jiménez-Romero1, Anthony Severdia2, Daniel Álvarez3, Manuel Grosso1, Antonio Arias1, Nicole Spivey2, Jibin Li2,  Pablo [...]

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition

Introduction P-glycoprotein (P-gp) is a drug transporter recommended by regulatory agencies for in-vitro and in-vivo DDI evaluation. Due to high inter-laboratory variability in in-vitro P-gp data, regulators [...]

2019-07-18T15:00:45-04:00July 18, 2019|Categories: AbsorbThis Blog, Drug Transporters|Tags: , , |

Metformin Clinical DDI Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision

Introduction Metformin is an orally administered drug prescribed for the treatment of Type 2 diabetes. It is known to decrease hepatic glucose production, by inhibiting gluconeogenesis, and [...]

Transporters In Drug Development Based On Recent ITC Recommendations

Introduction Transporters are membrane proteins highly expressed in various organs of humans. They play a pivotal role in the absorption and disposition of both endogenous and exogenous [...]