Drug Discovery and Development

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In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs

In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs Yuri Bukhtiyarov, Jibin Li, Nicole Spivey, Svitlana Silchenko, [...]

Webinar: Challenges in Adapting Neutralizing and Anti-Drug Antibody Assays to Gene Therapies

Webinar Download Originally Hosted: Thursday, October 10, 2019 11:00am - 12:00pm EDT Challenges in Adapting Neutralizing and Anti-Drug Antibody Assays to Gene Therapies This presentation summarizes a [...]

2019-10-14T14:15:39-05:00September 17, 2019|Categories: ACF Bioservices, Bioanalysis, Webinars|Tags: , |

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation

Perspectives From the International Transporter Consortium Introduction Transporter studies are performed at various stages of drug development ‒ discovery to first-in-human (FIH) phase (in-vitro substrate and inhibition [...]

2019-08-20T12:39:25-05:00August 20, 2019|Categories: AbsorbThis Blog, Drug Transporters|

Monitoring Oral Solid Dosage Forms Quality by NIR Spectroscopy and IDAS2

Monitoring Oral Solid Dosage Forms Quality by NIR Spectroscopy and IDAS2 Johayra Simithy1, Carlos Jiménez-Romero1, Anthony Severdia2, Daniel Álvarez3, Manuel Grosso1, Antonio Arias1, Nicole Spivey2, Jibin Li2,  Pablo [...]

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition

Introduction P-glycoprotein (P-gp) is a drug transporter recommended by regulatory agencies for in-vitro and in-vivo DDI evaluation. Due to high inter-laboratory variability in in-vitro P-gp data, regulators [...]

2019-07-18T15:00:45-05:00July 18, 2019|Categories: AbsorbThis Blog, Drug Transporters|Tags: , , |