Poster illustrating Assessing Systemic Toxicity and Therapeutic Efficacy of Atosiban and Nafarelin in a Rabbit Endometriosis Model



Endometriosis is a chronic, painful disease whose etiology remains unknown and affects roughly 6-10% of women.  The disease occurs when endometrial cells, which normally grow inside of the uterine body form and adhere outside the uterus. Symptoms of the disease include abdominal or pelvic pain and infertility.

Due to the unknown etiology of the disease,  current treatment for affected women ranges from laparoscopic removal of ectopic lesions and tissues from the reproductive tract to pharmacological pain management of the symptoms.  As a result, further research is necessary to determine the most effective and safe regimen to alleviate and/or prevent disease.

The goal of the autologous rabbit model of surgically induced endometriosis is to mimic the disease in women, and determine the toxicity of commonly used hormone therapies such as Atosiban (an Oxytocin receptor blocking agent) and Nafarelin (a Gonadotropin releasing hormone agonist). Confirmation of endometriosis was determined by clinical signs and post mortem intra-abdominal tissue evaluation.  At the designated time points and testing groups, animals were dosed with either Nafarelin or Atosiban (subcutaneously).  Upon scheduled endpoints, blood work (CBC-Chemistry) was done on the rabbits from all groups to detect any toxicity of the treatment doses versus no treatment. Endometrial tissue was excised from all groups and histologically analyzed to determine the efficacy of the  drug regimens.

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