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Our Express Services are optimized, screening-based protocols with deliverables securely provided in 5-10 business days. For definitive studies to support regulatory approval, or to customize our online store assays, please contact us.

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Detection of Glucuronides – Human Liver Microsomes

This assay is used to detect glucuronidation of a test compound after incubation with human liver microsomes in the presence of UDPGA Required from Customer Either a minimum of 1.2 […]

EA433

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Stability with Metabolite Detection – Phase I Metabolites and Glucuronidation Liver Microsomes

This assay is used to determine the metabolic stability of a test compound incubated with human, rat, dog, primate or mouse liver microsomes and to detect expected Phase I and Phase II metabolites.

EA453

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Metabolic Stability – Cyropreserved Hepatocytes

This assay is used to determine the percent remaining of a test compound incubated with cryopreserved hepatocytes (mouse, rat, dog, monkey, or human).

EA425

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Metabolic Stability – Liver S9 Fractions

This assay is used to determine the percent remaining of a test compound incubated with liver S9 fraction (mouse, rat, dog, monkey, or human) in the presence of cofactors.

EA424

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Metabolic Stability – Liver Microsomes

This assay is used to determine the percent remaining of a test compound incubated with human, rat, dog, primate or mouse liver microsomes in the presence of NADPH Catalog number.

EA401

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Time Dependent Inhibition – IC50 Shift

This assay is used to identify time-dependent inhibition of individual cytochrome P450 (CYP) enzymes by a test compound using the IC50 shift approach.

EA450

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UGT Inhibition – Recombinant Enzymes and LC-MS/MS

This assay is used to assess the potential of a test compound to inhibit individual human UDP-glucuronosyltransferase (UGT) isoforms

EA432

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CYP IC50 in Human Liver Microsomes – LC-MS/MS

This assay is used to determine the IC50 for reversible inhibition of individual cytochrome P450 (CYP) enzymes by a test compound.

EA427

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CYP Inhibition in Human Liver Microsomes – LC-MS/MS

This assay is used to screen for reversible inhibition of individual cytochrome P450 (CYP) enzymes by a single concentration of a test compound.

EA426

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Time Dependent CYP Inhibition – IC50 Shift

This assay is used to identify time-dependent inhibition of individual cytochrome P450 (CYP) enzymes by a test compound using the IC50 shift approach.

EA431

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CYP Phenotyping – Chemical Inhibitors

This assay is used to identify the CYP(s) involved in the metabolism of a test compound, through the use of human liver microsomes and CYP-specific chemical inhibitors.

EA428

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CYP Inhibition IC50 In Human Liver Microsomes – LC-MS/MS

This assay is used to determine the potency with which a test compound inhibits cytochrome P450 (CYP) enzymes.

EA413

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CYP Phenotyping – Supersomes™

This assay is used to identify the CYP(s) involved in the metabolism of a test compound, through the use of CYP-specific Supersomes.

EA408

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