Metabolic Stability - Expected Phase I and Phase II and Soft and Hard Reactive MetabolitesThis assay is used to determine the metabolic stability of a test compound incubated with human, rat, dog, primate or mouse liver microsomes and to detect expected Phase I, Phase II, and trapped reactive metabolites Catalog number EA452 Required from Customer Deliverables   Substrate Assay System Assay Conditions Assay QC Notes
  1. The results from this assay are sent to the customer in the ExpressPlus report format, which may include graphical representations of data and comparison with historical data for reference compounds.
  2. This assay does not provide stability information of test compound in liver microsomes without cofactors.
  3. Percent remaining at each time point is calculated from the peak area response ratio of test compound (or control) divided by the peak area response ratio of the 0-minute sample.
  4. In vitro intrinsic clearance (CLint in-vitro) = k/P (mL/min·mg protein), where k is the elimination rate constant (min-1) and P is the protein concentration (mg/mL).
  Price:  $1,147.00 per test article per matrix