This assay uses OCT1-transfected HEK293 cells to assess whether the test compound is a potential substrate of the hepatic uptake transporter OCT1.
8 results found for "OCT1 HEK293"
This assay is used to screen for inhibition of OCT1 by a test compound in OCT1-transfected HEK293 cells at a single concentration.
This assay is used to determine the IC50 of a test compound for inhibition of OCT1 in OCT1-transfected HEK293 cells.
Intestinal Uptake Transporters, Hepatic Uptake Transporters, Renal Uptake Transporters OATP2B1, OATP1B1, OAT1 OATP1A2, OATP1B3, OAT3 PepT1, OCT1, OCT2 Uptake transporter interaction assessments are performed at Absorption Systems using various uptake […]
Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]
OCT1 (SLC22A1) and OCT2 (SLC22A2) Transporters are validated, stable and robust cell-based assays OCT: What and Where The organic cation transporter (OCT) family of SLC22 transporters are expressed ubiquitously throughout […]
This assay is used to screen for inhibition of OCT2 by a test compound in OCT2-transfected HEK293 cells at a single concentration.
This OCT transporter assay is used to determine the IC50 of a test compound for inhibition of OCT2 in OCT2-transfected HEK293 cells.