This assay uses OATP1B3-transfected HEK293 cells to assess whether the test compound is a potential substrate of the hepatic uptake transporter OATP1B3
7 results found for "OATP1B3"
This OATP1B3 transporter assay is used to screen for inhibition of OATP1B3 by a test compound in OATP1B3-transfected HEK293 cells at a single concentration.
This assay is used to determine the IC50 of a test compound for inhibition of OATP1B3 in OATP1B3-transfected HEK293 cells.
Introduction Transporters are membrane proteins highly expressed in various organs of humans. They play a pivotal role in the absorption and disposition of both endogenous and exogenous molecules. In the […]
Intestinal Uptake Transporters, Hepatic Uptake Transporters, Renal Uptake Transporters OATP2B1, OATP1B1, OAT1 OATP1A2, OATP1B3, OAT3 PepT1, OCT1, OCT2 Uptake transporter interaction assessments are performed at Absorption Systems using various uptake […]
Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]
OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3), OATP1A2 (SLCO1A2) and OATP2B1 (SLCO2B1) Transporters OATP: What and Where The organic anion transporter polypedtides (OATPs; SLCO) represent a superfamily of transporters. Regardless of their name, […]