This assay uses OATP1B1-transfected HEK293 cells to assess whether the test compound is a potential substrate of the hepatic uptake transporter OATP1B1
6 results found for "OATP1B1 HEK293"
This assay is used to screen for inhibition of OATP1B1 by a test compound in OATP1B1-transfected HEK293 cells at a single concentration
This assay is used to determine the IC50 of a test compound for inhibition of OATP1B1 in OATP1B1-transfected HEK293 cells.
Intestinal Uptake Transporters, Hepatic Uptake Transporters, Renal Uptake Transporters OATP2B1, OATP1B1, OAT1 OATP1A2, OATP1B3, OAT3 PepT1, OCT1, OCT2 Uptake transporter interaction assessments are performed at Absorption Systems using various uptake […]
Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]
OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3), OATP1A2 (SLCO1A2) and OATP2B1 (SLCO2B1) Transporters OATP: What and Where The organic anion transporter polypedtides (OATPs; SLCO) represent a superfamily of transporters. Regardless of their name, […]