This assay is used to determine the interaction of a test article with P-gp using MDR1- MDCK cell monolayers with and without a P-gp inhibitor
8 results found for "MDR1-MDCK"
This MDR assay is used to screen for inhibition of P-gp by a test compound, by measuring its effect on the bidirectional permeability of a P-gp substrate through MDR1-MDCK cell monolayers.
This assay is used to determine the IC50 of a test compound for inhibition of P-gp in MDR1-MDCK cells
This assay is used to determine the blood-brain barrier (BBB) penetration potential of a test article using MDR1-MDCK cell monolayers.
P-glycoprotein 1 (P-gp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) P-gp: What and Where Permeability glycoprotein 1 (P-gp) is the well-known […]
Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]
Cell-Based Absorption Systems offers different cell lines such as Caco-2, MDCK-MDR1 which are well-established tools for predicting intestinal absorption of drug candidates. Advantages of cell monolayers: Established, robust in-vitro models, […]
Absorption Systems is proud to announce we are now accepting requests for our CellPortReadyTM Assay Ready Plates. Assay Plates and Assay Kits are available in 12 and 24-well formats. We are […]