8 results found for "MDR1-MDCK"

P-gp Inhibition – MDR1-MDCK

This MDR assay is used to screen for inhibition of P-gp by a test compound, by measuring its effect on the bidirectional permeability of a P-gp substrate through MDR1-MDCK cell monolayers.

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Transporters

Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]

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Permeability

Cell-Based Absorption Systems offers different cell lines such as Caco-2, MDCK-MDR1 which are well-established tools for predicting intestinal absorption of drug candidates. Advantages of cell monolayers: Established, robust in-vitro models, […]

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