7 results found for "BCRP-MDCK"

BCRP Inhibition Assessment – BCRP-MDCK

This BCRP transporter assay is used to screen for inhibition of BCRP by a test compound, by measuring its effect on the bidirectional permeability of a BCRP substrate through BCRP-MDCK cell monolayers

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Why evaluate the substrate and inhibitor potential of the investigational drug for specific transporters and why do the FDA and EMA care? Membrane transporters can have clinically relevant effects on […]

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Cell-Based Absorption Systems offers different cell lines such as Caco-2, MDCK-MDR1 which are well-established tools for predicting intestinal absorption of drug candidates. Advantages of cell monolayers: Established, robust in-vitro models, […]

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