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Metabolite Identification
As part of our drug metabolism program, Absorption Systems has a QTRAP, Orbitrap, and experienced analytical chemists who perform metabolite ID. We take a tiered approach, depending on your needs and the developmental stage of your compound(s). With this approach, you only pay for those capabilities that you need at the time and we can follow up with more intensive analyses as appropriate, from screening mode through GLP-level rigor.
NEW! LTQ Orbitrap XL from Thermo Scientific
Based on the fast and sensitive LTQ XL™ linear ion trap mass spectrometer and the Orbitrap mass analyzer, the LTQ Orbitrap XL hybrid Fourier Transform MS supports a wide range of applications, including metabolite ID and the most challenging quantitation of low-level components in complex biological matrices. Its outstanding mass accuracy, resolving power, dynamic range and high sensitivity combine to provide unrivaled performance and flexibility.
Absorption Systems has the LTQ Orbitrap XL. Contact us to learn how this exciting technology enhances what we can do for you!
Why should you do metabolite ID?
- Required by regulatory agencies
- Helps select the most appropriate nonclinical tox species based on exposure to all major human metabolites
- Predicts unique or disproportionate human metabolites
- Identifies metabolic “soft spots”
- Certain structural features may predict toxicity of metabolites
How does Absorption Systems do metabolite ID?
- Generate metabolites in vitro or in vivo
- Utilize high-resolution mass spec coupled with data-dependent acquisition of MS(n) data
- Perform structural elucidation
- Quantify and determine relative abundance of metabolites
- Use MetaSite software to complement the results from LC-MS/MS
- Available: Structure confirmation by NMR and synthesis of metabolites using biomimetic oxidation
Related Literature
This screening assay is used to detect putative metabolites of a test compound produced by expected biotransformations in pooled liver microsomes, S9 fraction, or hepatocytes.
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This screening assay is used to detect metabolites from expected biotransformations and perform putative structure assignment, after incubation of a test compound with pooled liver microsomes, S9 fraction, or hepatocytes.
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This assay is used to identify metabolites of a test compound produced by pooled liver microsomes, S9 fraction, or hepatocytes.
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This assay is used to identify and elucidate structures of metabolites of a test compound after incubation with pooled liver microsomes, S9 fraction, or hepatocytes.
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Brochures
Structural identification and/or quantification of drug metabolites
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