Because modulation of P-gp through inhibition or induction can lead to drug-drug interactions by ...
>> read moreThis purpose of this study was to investigate whether Madin-Darby canine kidney cells...
>> read morePurpose: The sedating effect of first generation H1-antihistamines has been...
>> read moreMolecular medicine has led to rapid advances in the characterization of hepatobiliary transport...
>> read moreThis review examines the use of Caco-2 monolayers in the prediction of intestinal drug...
>> read moreThe dispositions of 50 marketed central nervous system (CNS) drugs into the brain have been...
>> read moreTo determine and compare the relationship between in vivo oral absorption in humans and ...
>> read moreIn the present investigation, the uptake and transport kinetics of valacyclovir were studied in...
>> read moreP-glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter, functions...
>> read moreThe permeability surface area (PS) product, an index of permeability of the blood-brain barrier...
>> read moreThe clinical pharmacokinetics and in vitro inhibition of digoxin were examined to...
>> read moreThe potential for interactions between new medicinal products and already marketed drugs should...
>> read moreRecent studies have revealed the import role played by transporters in the renal and...
>> read moreThe objectives of this study were to (1) characterize MDR-MDCK monolayers as an in...
>> read moreThis guidance provides recommendations for sponsors of new drug applications (NDAs) and...
>> read moreCompounds known to modulate P-glycoprotein (P-gp) activity were evaluated in cell monolayers...
>> read moreThe functional expression of P-glycoprotein has been studied in confluent epithelial layers of...
>> read moreThe wealth of information that has emerged in recent years detailing the substrate specificity...
>> read moreMembrane transporters can be major determinants of the pharmacokinetic, safety and efficacy...
>> read moreOverexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance ...
>> read moreThe present study evaluates the impact of P-glycoprotein (P-gp) on plasma-brain disposition and...
>> read moreThe clearance route and the absolute values for hepatic and renal clearance of drugs are...
>> read moreThe intrinsic metabolic clearance of saquinavir, nelfinavir, and ritonavir was determined over a ...
>> read moreP-glycoprotein (P-gp) affects the absorption, distribution, and clearance of a variety of...
>> read moreRecently, increased interest in drug transporters and research in this area has revealed that...
>> read moreThe disposition of seven marketed and two AstraZeneca acid (organic anion) compounds with a...
>> read moreIt has been reported that conjugating acyclovir, a potent antiviral with low oral...
>> read moreThe wealth of information that has emerged in recent years detailing the substrate specificity...
>> read moreThe objective of the present study was to determine the efflux transporters responsible for acid ...
>> read more