Scientific Literature

Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

The dispositions of 50 marketed central nervous system (CNS) drugs into the brain have been...

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Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding

A 96-well equilibrium dialysis block was designed and constructed that is compatible with most...

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Drug-protein binding and blood-brain barrier permeability

The permeability surface area (PS) product, an index of permeability of the blood-brain barrier...

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Human and animal hepatocytes in vitro with extrapolation in vivo

Human and animal hepatocytes are now being used as an in vitro technique to aid drug...

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In silico prediction of blood–brain barrier permeation

This review examines the progress that is being made towards the in silico prediction of brain...

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PH-metric log P 11. pKa determination of water-insoluble drugs in organic solvent-water mixtures

Apparent acid dissociation constants (p(s)Ka) of two water-insoluble drugs, ibuprofen and...

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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

This review begins with a general presentation of the new paradigm of drug discovery, with its...

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Role of pharmacokinetics and metabolism in drug discovery and development

Drug research encompasses several diverse disciplines united by a common goal, namely the...

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Stability of drug concentrations in plasma stored in serum separator blood collection tubes

The stability of therapeutic concentrations of 11 drugs and two trace elements (copper and zinc) ...

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Strategies for absorption screening in drug discovery and development

This review gives an overview of the current approaches to evaluate drug absorption potential in ...

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Whatever happened to cassette-dosing pharmacokinetics?

Cassette dosing is a procedure that is used for rapidly assessing the pharmacokinetics of a...

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