This purpose of this study was to investigate whether Madin-Darby canine kidney cells...
>> read morePurpose: The sedating effect of first generation H1-antihistamines has been...
>> read moreBiopharmaceutics Classification Systems is a regulatory mechanism through which you can obtain a...
>> read moreThe tenets of biopharmaceutics, solubility and permeability, are of pivotal importance in new...
>> read moreLiterature and experimental data relevant to the decision to allow a waiver of in vivo...
>> read moreThis review examines the use of Caco-2 monolayers in the prediction of intestinal drug...
>> read moreCaco-2 cells develop morphologic characteristics of normal enterocytes when grown on plastic...
>> read moreTo determine and compare the relationship between in vivo oral absorption in humans and ...
>> read moreThe purpose of this study was to develop and validate a method for separately evaluating the...
>> read moreThe objectives of this study were to (1) characterize MDR-MDCK monolayers as an in...
>> read moreThe functional expression of P-glycoprotein has been studied in confluent epithelial layers of...
>> read moreThis guidance provides recommendations for sponsors of investigational new drug applications...
>> read moreIn percutaneous absorption studies the potency of penetration of chemical substances is often...
>> read moreThe preliminary work was presented at the meeting of the Expert Panel on Biopharmaceutics Drug...
>> read moreDrug development is a risky business. Success or failure often depends on selecting one or two...
>> read moreOverexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance ...
>> read moreA panel of researchers and experts from leading universities and major pharmaceutical companies...
>> read moreThe present study evaluates the impact of P-glycoprotein (P-gp) on plasma-brain disposition and...
>> read morePURPOSE: The aim of this research was to develop a pH-dependent canine absorption model for...
>> read moreThe pharmacokinetics of fluvastatin, a potent inhibitor of hydroxymethylglutaryl-CoA reductase...
>> read moreThis review begins with a general presentation of the new paradigm of drug discovery, with its...
>> read moreRecently, increased interest in drug transporters and research in this area has revealed that...
>> read moreOne of the fundamental challenges drug metabolism scientists face in drug discovery and...
>> read moreThe stability of therapeutic concentrations of 11 drugs and two trace elements (copper and zinc) ...
>> read moreBy adding high concentrations of test drugs to an Ussing chamber with rat jejunum, we...
>> read moreThe human intestinal Caco-2 cell line has been extensively used over the last twenty years as a...
>> read moreBioavailability (BA) and bioequivalence (BE) play a central role in pharmaceutical product...
>> read moreIt has been reported that conjugating acyclovir, a potent antiviral with low oral...
>> read more