The accuracy of in vitro inhibition parameters in scaling to in vivo drug-drug ...
>> read moreClinically observed drug interactions with cytochrome p450 (p450) enzymes have increased the...
>> read moreIt is widely accepted that today’s practice of polypharmacy inevitably increases the...
>> read moreBecause modulation of P-gp through inhibition or induction can lead to drug-drug interactions by ...
>> read moreDuring the perioperative period, gastric emptying rate and first-pass metabolism limit the use...
>> read moreIn order to determine whether a drug shows the potential for percutaneous absorption, both...
>> read moreA novel liquid chromatography/tandem mass spectrometry (LC-MS/MS)-based depletion method for...
>> read moreCardiovascular diseases are the first leading cause of death and morbidity in developed...
>> read moreThis purpose of this study was to investigate whether Madin-Darby canine kidney cells...
>> read morePurpose: The sedating effect of first generation H1-antihistamines has been...
>> read moreBiopharmaceutics Classification Systems is a regulatory mechanism through which you can obtain a...
>> read moreMolecular medicine has led to rapid advances in the characterization of hepatobiliary transport...
>> read moreThe prediction of drug metabolism is an important task in drug development. Besides...
>> read moreThe tenets of biopharmaceutics, solubility and permeability, are of pivotal importance in new...
>> read moreLiterature and experimental data relevant to the decision to allow a waiver of in vivo...
>> read moreThis review examines the use of Caco-2 monolayers in the prediction of intestinal drug...
>> read moreOxidation reactions are of fundamental importance in nature, and are key transformations in...
>> read moreThe dispositions of 50 marketed central nervous system (CNS) drugs into the brain have been...
>> read moreCaco-2 cells develop morphologic characteristics of normal enterocytes when grown on plastic...
>> read moreTo determine and compare the relationship between in vivo oral absorption in humans and ...
>> read morePURPOSE: To evaluate the distribution of allometric exponents for relationship of total plasma...
>> read moreInduction of cytochrome P450 (CYP) by drugs is one of major concerns for drug-drug interactions. ...
>> read moreCryopreserved human hepatocytes were extensively characterized in our laboratory. The post-thaw...
>> read moreMarker substrates, chemical inhibitors, and inhibitory antibodies are important tools for the...
>> read moreIn the present investigation, the uptake and transport kinetics of valacyclovir were studied in...
>> read moreA 96-well equilibrium dialysis block was designed and constructed that is compatible with most...
>> read moreP-glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter, functions...
>> read moreThe objective of this article is to encourage those studying ligand interactions with...
>> read moreThe permeability surface area (PS) product, an index of permeability of the blood-brain barrier...
>> read moreThe clinical pharmacokinetics and in vitro inhibition of digoxin were examined to...
>> read moreCultured human hepatocytes are a valuable in vitro system for evaluating new molecular...
>> read moreThe potential for interactions between new medicinal products and already marketed drugs should...
>> read moreThe purpose of this study was to develop and validate a method for separately evaluating the...
>> read moreRecent studies have revealed the import role played by transporters in the renal and...
>> read moreThe objectives of this study were to (1) characterize MDR-MDCK monolayers as an in...
>> read moreThis guidance provides recommendations for sponsors of new drug applications (NDAs) and...
>> read moreHuman liver microsomal flavin-containing monooxygenase activity has been studied using...
>> read moreCompounds known to modulate P-glycoprotein (P-gp) activity were evaluated in cell monolayers...
>> read moreThe functional expression of P-glycoprotein has been studied in confluent epithelial layers of...
>> read moreThe plasma concentration-time profiles of cimetidine often exhibit two peaks following oral...
>> read moreUridine 5′-diphospho-N-acetylgalactosamine glycosyltransferases (UGTs) and...
>> read moreThe purpose of this guidance is to provide recommendations to sponsors for the development of...
>> read moreThis guidance provides recommendations for sponsors of investigational new drug applications...
>> read moreHuman and animal hepatocytes are now being used as an in vitro technique to aid drug...
>> read moreThe cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are responsible ...
>> read moreIn vertebrates, the glucuronidation of small lipophilic agents...
>> read moreThe wealth of information that has emerged in recent years detailing the substrate specificity...
>> read moreThis review examines the progress that is being made towards the in silico prediction of brain...
>> read moreDP glycosyltransferases (UGTs) and sulfotransferases (SULTs) are phase II enzymes that interact...
>> read moreThe purpose of this study was to investigate transport and metabolism contributions to low...
>> read moreIn percutaneous absorption studies the potency of penetration of chemical substances is often...
>> read moreThe preliminary work was presented at the meeting of the Expert Panel on Biopharmaceutics Drug...
>> read moreThe study of the metabolic fate of drugs is an essential and important part of the drug...
>> read moreDrug development is a risky business. Success or failure often depends on selecting one or two...
>> read moreMembrane transporters can be major determinants of the pharmacokinetic, safety and efficacy...
>> read moreThe metabolism and disposition of...
>> read moreOverexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance ...
>> read moreEvaluation of a Novel Molecular Therapy as Means for Restoring Cardiac Function Subsequent to a...
>> read moreA panel of researchers and experts from leading universities and major pharmaceutical companies...
>> read moreThe present study evaluates the impact of P-glycoprotein (P-gp) on plasma-brain disposition and...
>> read moreThe Ussing chamber diffusion system was used as a model to study the apparent permeability...
>> read morePURPOSE: The aim of this research was to develop a pH-dependent canine absorption model for...
>> read moreApparent acid dissociation constants (p(s)Ka) of two water-insoluble drugs, ibuprofen and...
>> read moreTo 12 healthy male volunteers, 6 smokers and 6 non-smokers, 10 mg/kg antipyrine (phenazone) was...
>> read moreThe pharmacokinetics of fluvastatin, a potent inhibitor of hydroxymethylglutaryl-CoA reductase...
>> read moreThis review begins with a general presentation of the new paradigm of drug discovery, with its...
>> read moreThe clearance route and the absolute values for hepatic and renal clearance of drugs are...
>> read moreThe intrinsic metabolic clearance of saquinavir, nelfinavir, and ritonavir was determined over a ...
>> read moreP-glycoprotein (P-gp) affects the absorption, distribution, and clearance of a variety of...
>> read moreDrug research encompasses several diverse disciplines united by a common goal, namely the...
>> read moreRecently, increased interest in drug transporters and research in this area has revealed that...
>> read moreRelatively few selective substrate and inhibitor probes have been identified for human...
>> read moreDrugs can be metabolically activated to soft and hard electrophiles, which are readily trapped...
>> read moreOne of the fundamental challenges drug metabolism scientists face in drug discovery and...
>> read moreThe stability of therapeutic concentrations of 11 drugs and two trace elements (copper and zinc) ...
>> read moreThis review gives an overview of the current approaches to evaluate drug absorption potential in ...
>> read moreThe high-throughput screening in drug discovery for absorption, distribution, metabolism and...
>> read moreBy adding high concentrations of test drugs to an Ussing chamber with rat jejunum, we...
>> read moreThe human intestinal Caco-2 cell line has been extensively used over the last twenty years as a...
>> read moreCurrent regulatory guidances do not address specific study designs for in vitro and...
>> read moreTime-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular...
>> read moreThe effect of various in vitro conditions on the permeability characteristics of the...
>> read moreThe disposition of seven marketed and two AstraZeneca acid (organic anion) compounds with a...
>> read moreThe medical literature describes numerous in vitro and in vivo wound-healing models. The selection...
>> read moreBioavailability (BA) and bioequivalence (BE) play a central role in pharmaceutical product...
>> read moreIt has been reported that conjugating acyclovir, a potent antiviral with low oral...
>> read moreThis study was designed 1) to examine the effects of blood-brain barrier (BBB)...
>> read moreThe wealth of information that has emerged in recent years detailing the substrate specificity...
>> read moreA new type of quadrupole linear ion trap mass spectrometer, Q TRAPTM LC/MS/MS system...
>> read moreThe objective of the present study was to determine the efflux transporters responsible for acid ...
>> read moreThe ability of hepatic microsomal metabolic stability assessments to predict in vivo...
>> read moreCassette dosing is a procedure that is used for rapidly assessing the pharmacokinetics of a...
>> read more