Below is a list of selected predesigned and customizable assays and studies. Each assay data sheet includes the required materials, study methods, options, and deliverables for that particular study. For ExpressPlus™ assays, please download our in vitro or in vivo order form. 

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• ExpressPlus ABT Exposure in Rats
• ExpressPlus BBB Penetration Potential Determined Using MDR1-MDCK Cell Monolayers
• ExpressPlus BCRP IC₅₀ Determination Using BCRP-MDCK Cells
• ExpressPlus BCRP Inhibition Assessment in BCRP-MDCK Cells
• ExpressPlus BCRP Substrate Assessment in BCRP-MDCK Cells (+/- Inhibitor)
• ExpressPlus BCRP Substrate Assessment in Caco-2 Cells (+/- Inhibitor)
• ExpressPlus Bidirectional Permeability Through Caco-2 Cell Monolayers
• ExpressPlus Blood to Plasma Partitioning in Mice, Rats, or Humans
• ExpressPlus Brain to Plasma Ratio in Rats or Mice
• ExpressPlus BSEP IC₅₀ Determination Using Vesicles
• ExpressPlus BSEP Inhibition Assessment Using Vesicles
• ExpressPlus CYP IC₅₀ in Human Liver Microsomes Using LC-MS/MS
• ExpressPlus CYP Inhibition in Human Liver Microsomes Using LC-MS/MS
• ExpressPlus Detection of Glucuronides in Human Liver Microsomes
• ExpressPlus Dog PK
• ExpressPlus Dog PK (Non-Crossover)
• ExpressPlus Formulation Assessment
• ExpressPlus Fraction Unbound (Rat or Mouse Brain)
• ExpressPlus Glutathione and Cyanide Trapping in Human Liver Microsomes
• ExpressPlus Glutathione Trapping in Human Liver Microsomes
• ExpressPlus LogD By Shake Flask
• ExpressPlus Metabolic Stability In Cyropreserved Hepatocytes
• ExpressPlus Metabolic Stability in Dog Liver Microsomes
• ExpressPlus Metabolic Stability in Human Liver Microsomes
• ExpressPlus Metabolic Stability in Liver S9 Fraction
• ExpressPlus Metabolic Stability in Mouse Liver Microsomes
• ExpressPlus Metabolic Stability in Primate Liver Microsomes
• ExpressPlus Metabolic Stability in Rat Liver Microsomes
• ExpressPlus Mouse PK
• ExpressPlus MRP2 Substrate Assessment in Caco-2 Cells (+/- Inhibitor)
• ExpressPlus Non-Human Primate PK (Crossover)
• ExpressPlus Non-Human Primate PK (Non-Crossover)
• ExpressPlus OAT1 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OAT1 Inhibition Assessment Using Transfected Cells
• ExpressPlus OAT3 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OAT3 Inhibition Assessment Using Transfected Cells
• ExpressPlus OATP1B1 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OATP1B1 Inhibition Assessment Using Transfected Cells
• ExpressPlus OATP1B3 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OATP1B3 Inhibition Assessment Using Transfected Cells
• ExpressPlus OCT1 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OCT1 Inhibition Assessment Using Transfected Cells
• ExpressPlus OCT2 IC₅₀ Determination Using Transfected Cells
• ExpressPlus OCT2 Inhibition Assessment Using Transfected Cells
• ExpressPlus P-gp IC₅₀ Determination Using Caco-2 Cells
• ExpressPlus P-gp IC₅₀ Determination Using MDR1-MDCK Cells
• ExpressPlus P-gp Inhibition Assessment in Caco-2 Cells
• ExpressPlus P-gp Inhibition Assessment in MDR1-MDCK Cells
• ExpressPlus P-gp Substrate Assessment in Caco-2 Cells (+/- Inhibitor)
• ExpressPlus P-gp Substrate Assessment in MDR1-MDCK Cells (+/- Inhibitor)
• ExpressPlus PepT1 Substrate Assessment in Caco-2 Cell Monolayers
• ExpressPlus Plasma Protein Binding in Dog Plasma
• ExpressPlus Plasma Protein Binding in Human Plasma
• ExpressPlus Plasma Protein Binding in Mouse Plasma
• ExpressPlus Plasma Protein Binding in Primate Plasma
• ExpressPlus Plasma Protein Binding in Rat Plasma
• ExpressPlus Rabbit PK
• ExpressPlus Rat PK
• ExpressPlus Solubility By Shake Flask
• ExpressPlus Stability In Buffer
• ExpressPlus Stability In Plasma or Whole Blood
• ExpressPlus Time Dependent Inhibition With and Without NADPH
• ExpressPlus Time Dependent Inhibition With and Without Pre-Incubation
• ExpressPlus UGT Inhibition Using Recombinant Enzymes and LC-MS/MS
• ExpressPlus Unidirectional Permeability Through Caco-2 Cell Monolayers
• k_i Determination In Human Liver Microsomes
• Acute Systemic Toxicity of Medical Devices or Device Materials
• Barriers to Bioavailability in Dogs
• Barriers to Bioavailability in Rats
• BCRP Interaction Assessment in BCRP-transfected MDCK Cells
• BCRP Interaction Assessment in Caco-2 Cells
• Bidirectional Permeability Through Caco-2 Cell Monolayers
• Bidirectional Permeability Through Intestinal Tissue
• Bile Duct Cannulation in Dogs
• Blood to Plasma Partitioning in Mice, Rats, or Humans
• Brain to Plasma Ratio in Rats or Mice
• BSEP Interaction Assessment in Vesicles
• Cell Cytotoxicity
• CYP IC₅₀ Determination Using Fluorogenic Substrates
• CYP Inhibition IC₅₀ In Human Liver Microsomes Using LC-MS/MS
• CYP Inhibition Screen In Human Liver Microsomes Using LC-MS/MS
• CYP Inhibition Screen Using Fluorogenic Substrates
• CYP Reaction Phenotyping Using Chemical Inhibitors
• CYP Reaction Phenotyping Using Supersomes™
• Dog PK
• FMO Substrate Assessment Using Human Liver Microsomes
• FMO Substrate Assessment Using Supersomes™
• GLP 14 Day Repeat Dosing Toxicology in Rats
• GLP BCS Permeability Classification Using Caco-2 Cell Monolayers
• GLP BCS Solubility Classification by Shake-Flask
• Glutathione Trapping in Human Liver Microsomes
• Hemolysis
• Hepatocyte Cytotoxicity
• Human P-gp Substrate Assessment Across MDR1-MDCK Cell Monolayers
• Induction of CYP In Rabbit or Dog Hepatocytes
• Induction of CYP1A2, 2B6, and 3A In Fresh or Cryopreserved Human Hepatocytes
• Induction of P-gp in a Human Intestinal Cell Line
• Irritation Tests of Device Materials
• LogD By Shake Flask
• MAO Substrate Assessment Using Human Liver S9 Fraction
• MAO Substrate Assessment Using Supersomes™
• MATE1 Interaction Assessment in MATE1-transfected HEK293 Cells
• MATE2-K Interaction Assessment in MATE2-K-transfected HEK293 Cells
• Maximum Tolerated Dose in Dogs
• Maximum Tolerated Dose in Rats
• Mechanism-based CYP Inhibition In Human Liver Microsomes Using LC-MS/MS
• Metabolic Stability in Either Cryopreserved or Fresh Hepatocytes
• Metabolic Stability in Human Intestinal Microsomes
• Metabolic Stability in Liver Microsomes
• Metabolic Stability in S9 Fraction
• Metabolite Identification In Vitro With Structure Elucidation (Level 2)
• Metabolite Identification In Vitro Without Structure Elucidation (Level 1)
• Metabolite Identification Using Microsomal or S9 Fractions
• Minipig PK
• Mouse PK
• MRP2 Interaction Assessment in Caco-2 Cells
• Non-Human Primate PK
• OAT1 Drug Interaction Assessment in OAT1-Transfected Cells
• OAT3 Drug Interaction Assessment in OAT3-Transfected Cells
• OATP1A2 Drug Interaction Assessment in OATP1A2-Transfected Cells
• OATP1B1 Drug Interaction Assessment in OATP1B1-Transfected Cells
• OATP1B3 Drug Interaction Assessment in OATP1B3-Transfected Cells
• OATP2B1 Drug Interaction Assessment in OATP2B1-Transfected Cells
• OCT1 Interaction Assessment in OCT1-transfected HEK293 Cells
• OCT2 Interaction Assessment in OCT2-transfected HEK293 Cells
• P-gp Interaction Assessment in Caco-2 Cells
• P-gp Interaction Assessment in hP-gp-transfected MDCK Cells
• pKa, LogP and LogD Determined By Potentiometric Titration
• Plasma Protein Binding using Equilibrium Dialysis
• Plasma Protein Binding using Ultracentrifugation
• Plasma Protein Binding using Ultrafiltration
• Preliminary BCS Permeability Classification Using Caco-2 Cell Monolayers
• Preliminary BCS Solubility Classification by Shake-Flask
• Rat Brain Perfusion
• Rat Carotid Infusion
• Rat PK
• Safety Testing of Implanted Devices
• Screening Metabolite Identification In Vitro With Structure Assignment
• Screening Metabolite Identification In Vitro Without Structure Elucidation
• Solubility By Shake Flask
• Stability In Buffer
• Stability In Gastric Fluids
• Sub-chronic Toxicity of Device Materials
• Time Dependent Inhibition Using the IC₅₀ Shift Approach
• UGT Inhibition Using Recombinant Enzymes and LC-MS/MS
• Unidirectional Permeability Through Caco-2 Cell Monolayers
• Unidirectional Permeability Through Excised Skin
• Unidirectional Permeability Through Intestinal Tissue
• Unidirectional Permeability Through Porcine Buccal Epithelium
• Unidirectional Permeability Through Porcine Nasal Epithelium
• Unidirectional Permeability Through Rabbit Cornea or Conjunctiva Level 1
• Unidirectional Permeability Through Rabbit Cornea or Conjunctiva Level 2