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Preclinical Services
- Barriers to Bioavailability
- Binding and Distribution
- Bioanalysis
- Bioavailability and Exposure
- BCS Classification
- CellPort® Drug Transporters
- Custom Services
- Dose Vehicle Assessment
- Ex Vivo Tissue Permeability
- ExpressPlus™
- Formulation Development
- In Situ Organ Perfusion
- Metabolism
- Metabolite ID and Production
- Ocular Models
- Permeability
- Physicochemical
- PK and Biodistribution
- SafetySuite™
- Toxicology
- Biologics
- Medical Devices
- Ocular
Ocular PK and Biodistribution
Don't Try to Infer PK from an Efficacy Study. . . Let Absorption Systems Measure It
Absorption Systems offers in vivo ocular PK studies in large and small animals, including distribution among various ocular tissues (aqueous humor, vitreous humor, retina, iris/ciliary body, etc.).
Large and small animals
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Rabbits |
Dogs |
Pigs |
Small Ruminants |
Rodents |
As an example, the ophthalmic drug timolol demonstrates significant accumulation in the aqueous humor and a measurable concentration in the retina within 30 minutes of topical administration to New Zealand White (NZW) rabbits. Many other dose routes are possible, from oral to intravenous to specialized ophthalmic routes such as subconjunctival and intravitreal.
Pre Tox
Exaggerated Dosing/Tolerability
Pilot Studies
Proof of Concept & Disease Models
Glaucoma
Age-Related Macular Degeneration (AMD)
Uveitis
Optic Nerve Neuropathy
Keratoconjunctivitis Sicca (KCS)
Corneal Wound Healing
Infectious Keratitis
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Simplified with Exemplary Service |