Assay Data Sheets

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Time Dependent Inhibition Using the IC50 Shift Approach

This assay is used to identify time-dependent inhibition of individual cytochrome P450 (CYP) enzymes by a test compound using the IC50 shift approach Catalog number EA450 Required from Customer [...]

December 28, 2015|Categories: Metabolism|Tags: |

Metabolic Stability – Expected Phase I and Phase II and Soft and Hard Reactive Metabolites

This assay is used to determine the metabolic stability of a test compound incubated with human, rat, dog, primate or mouse liver microsomes and to detect expected Phase [...]

December 28, 2015|Categories: Metabolism|Tags: |

Metabolic Stability – Phase I and Phase II Metabolites Only

This assay is used to determine the metabolic stability of a test compound incubated with human, rat, dog, primate or mouse liver microsomes and to detect expected Phase [...]

December 28, 2015|Categories: Metabolism|Tags: |

ExpressPlus Metabolic Stability in Liver Microsomes

This assay is used to detect expected metabolites and determine the percent remaining of a test compound incubated with human, rat, dog, primate or mouse liver microsomes in [...]

December 28, 2015|Categories: Metabolism|Tags: |

ExpressPlus OATP1B3 Substrate Assessment in OATP1B3-Transfected Cells

ExpressPlus OATP1B3 Substrate Assessment in OATP1B3-Transfected Cells This assay uses OATP1B3-transfected HEK293 cells to assess whether the test compound is a potential substrate of the hepatic uptake transporter [...]

December 28, 2015|Categories: Drug Transporters|Tags: |