Perfusion models offered by Absorption Systems focus on intestinal absorption (in situ intestinal perfusion), penetration of the blood-brain barrier (in situ brain perfusion), and biliary excretion (isolated liver perfusion).
Permeability of a drug either across or into a very specific tissue is often of crucial importance in order for a drug to be effective and/or effectively cleared from the body. While pharmacokinetic studies provide a complete picture of a drug’s bioavailability and disposition, in some instances a more mechanistic approach is required to truly understand what is going on “behind the scenes.” Organ perfusion models minimize interference from other physiological factors present in pharmacokinetic studies.
Rat intestinal perfusion (single pass, recirculating, closed loop)
Rat brain perfusion
Rat liver perfusion
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