CellPort Drug Transporter Assays

Drug Transporter Models that the FDA and EMA Guidance Requires

The FDA and EMA guidance now requires extensive testing of drug transporters. We have the most definative drug transporter test systems. CellPort Technologies^® is the brand name for all of Absorption Systems’ transporter-related services and platforms, including cell lines and assay formats. Some of them are proprietary and available exclusively through Absorption Systems…all of them provide the definitive data you need.

Clinically Relevant Drug Transporters

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Why evaluate drug transporters?

1. Regulatory Requirements
The FDA, EMA, and other drug regulatory agencies require it.

2. Pharmacokinetics
Drug transporters can have an enormous influence on the pharmacokinetics of their substrates; by influencing drug concentrations in plasma and/or at pharmacological sites of action, transporters can impact both safety and efficacy. In order to understand the pharmacokinetics of a new drug candidate, you need to know which transporters, if any, it interacts with.

3. Drug-Drug Interactions
Your compound could be either a perpetrator or victim of drug-drug interactions (DDIs) involving other drugs that interact with the same transporter. This could require dose adjustment, particularly for a drug with a narrow therapeutic index. Absorption Systems’ proprietary cell lines allow pharmaceutical and biotechnology companies to definitively predict clinical DDIs involving drug transporters.

Why not wait until my drug gets into the clinic?

Why wait? Do it now…in vitro! Our assays provide definitive data, quickly and cost-effectively. We use the same validated test systems, with different degrees of rigor, all the way from early screening to an NDA. In vitro drug interaction studies help predict the risk of clinical drug-drug interactions, contribute to the design of appropriate in vivo drug interaction studies (or, if the results are negative, make in vivo studies unnecessary), and support appropriate labeling. Plus, because our Caco-2 cell assay is dually validated for permeability and efflux transporter interactions, you may be able to avoid a clinical transporter interaction study even if your compound is a substrate for P-gp or BCRP.

Learn more about our exclusive CellPort Technologies assays
Learn more about predicting active uptake by transporters
Learn more about drug transporter tools and methods
Download the comprehensive Transporter Reference Guide
Learn more about drug safety testing with SafetySuite™

Transporter Assays
View all drug transporter assays

View the CellPort Drug Transporter Services Portfolio
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View the CellPort Technologies Video