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Preclinical Services
- Barriers to Bioavailability
- Binding and Distribution
- Bioanalysis
- Bioavailability and Exposure
- BCS Classification
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Bioavailability and Exposure
Rugged and Validated Predefined and Custom Designed Assays
In drug development it is critical to understand the bioavailability, particularly orally, of a candidate. Poor oral bioavailability can result in inconsistent exposure, multiplied by a lack of appreciation for the candidate's specific bioavailability-limiting properties. Absorption Systems scientists have the tools and expertise to determine a drug compound's absorption rate and barriers to bioavailability, including our exclusive ABT model, which can distinguish between first-pass metabolism and absorption.
Learn more about bioavailability and exposure tools and methods. Learn more about bioavailability and exposure assays. More about barriers to bioavailability for IND-enabling. View all assays
Bioavailability and Exposure Assays
Pharmacokinetics
Dose Vehicle Assessment
Brain to Plasma Ratio
Species: Mouse, Rat, Rabbit, Dog, Monkey, Minipig
Dose Routes: IV, Oral, Subcutaneous, IP, Buccal, Sublingual
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Recommended Resources
Induction Effects of Chemical Inducers on CYP3A Enzyme Activity in Fresh Dog and Rabbit HepatocytesGastric pH influences the appearance of double peaks in the plasma concentration-time profiles of cimetidine after oral administration in dogs
SafetySuite Metabolism and Transporter Package