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Barriers to Bioavailability
Barriers to Bioavailability
Are you faced with these challenges?
Identify your compounds’ barriers to bioavailability
The most desirable route of administration for any drug is oral, for reasons of patient compliance and marketability. However, there are significant obstacles which an oral compound must overcome in order to become systemically available. Instability in the gastric milieu, solubility in the GI tract, intestinal absorption 
(dictated by both passive permeability and transporter interactions), and metabolism by enzymes in the gut and liver are some of the major challenges.
"We have the knowledge and expertise to establish surgically modified animals and interpret the data to guide your compound’s advancement."
Learn more about barriers to bioavailability tools and methods Learn more about barriers to bioavailability assays More about bioavailability and exposure for lead optimization View all assays
Species: Rat and Dog