PK and Biodistribution

Rugged and Validated Predefined and Custom Designed Assays

Obtaining data from preclinical pharmacokinetic (PK) studies is one of the most important steps in the development of a new chemical entity (NCE). While the study itself provides the time course of the variation of a drug’s concentration in various body tissues, usually plasma following dosing, the data generated serves several other purposes. Such uses include determining the appropriate route of administration, relating plasma levels to efficacy and toxicity, determining frequency of dosing, as well as predicting human PK profiles through allometric scaling. PK models offered by Absorption Systems focus on determining bioavailability, relative exposure and tissue distribution.

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 Learn more about PK and biodistribution tools and methods
 Learn more about PK and biodistribution assays
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PK and Biodistribution Assays
Express PK
Express Dog PK (Non-crossover)
Express Monkey PK (Non-crossover)
Express ABT PK in Rodents
Express Brain to Plasma Ratio in Rodents
Absolute Bioavailability
Brain to Plasma Ratio in Rodent

Species: Rat, Mouse, Guinea Pig, Rabbit, Dog, Monkey, Pig, Minipig, Sheep, Goat
Dose Routes: Intravenous, Oral, Intraperitoneal, Sublingual, Buccal, Transdermal, Intraduodenal, Subcutaneous, Intracolonic, Intramuscular, Intratracheal, Ocular, and more