Absorption Systems uses a number of cell-based models for in vitro drug interaction testing to identify and characterize interactions between our customers' compounds and drug transporters. View the new ebook, Transporter Reference Guide .
Why should you care about transporters?
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View the new ebook, Transporter Reference Guide .
Click here to link to the 2006 FDA draft guidance on studies for drug-drug interactions: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM072101.pdf
Please contact Absorption Systems to help you determine whether your compounds interact with drug transporters.
Click here for more information on CellPort Technologies™, our proprietary cell lines for identifying interactions with drug transporters.
This assay is used to determine the permeability of a test compound through Caco-2 cell monolayers in the apical-to-basolateral and basolateral- to-apical direction.
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This assay is used to determine the P-gp interaction with a test compound using MDR1-MDCK cell monolayers in both the presence and absence of a P-gp inhibitor.
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This assay is used to determine the bidirectional permeability of a test compound through intestinal tissue segments (duodenum, ileum, jejunum and colon).
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This assay is used to determine the permeability of a test compound through Caco-2 cell monolayers in both the apical-to-basolateral and basolateral-to-apical direction.
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This assay is used to determine if a test compound is a human P-gp substrate by measuring its bidirectional permeability across MDR1-MDCK and MDCK cell monolayers in the presence and absence of P-gp inhibitors.
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This assay is used to determine if a test compound is a P-gp inhibitor by measuring its effect on the bidirectional permeability of the P-gp substrate, digoxin, through MDR1-MDCK or Caco-2 cell monolayers.
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This assay is used to screen for inhibition of P-gp by a test compound, by measuring its effect on the bidirectional permeability of a P-gp substrate through Caco-2 cell monolayers.
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This assay is used to identify active uptake of a test compound by PepT1, using the Caco-2 cell monolayer system.
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This assay is used to determine the IC50 of a test compound for inhibition of OATP1B1 in OATP1B1-transfected HEK293 cells.
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This assay is used to evaluate the potential of a test compound to inhibit OATP1B1 in OATP1B1-transfected HEK293 cells at a single concentration.
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This assay is used to determine the IC50 of a test compound for inhibition of OATP1B3 in OATP1B3-transfected HEK293 cells.
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This assay is used to evaluate the potential of a test compound to inhibit OATP1B3 in OATP1B3-transfected HEK293 cells at a single concentration.
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This assay uses CPT-B1 (BCRP-knockdown), CPT-P1 (P-gp-knockdown), and Caco 2 cell monolayers to determine if a test compound is a substrate and/or inhibitor of BCRP.
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This assay uses CPT-B1 (BCRP-knockdown), CPT-P1 (P-gp-knockdown), and Caco-2 cell monolayers to determine if a test compound is a substrate and/or inhibitor of BCRP.
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This assay is used to determine the P-gp interaction with a test compound using CellPort™ CPT-B1 BCRP-knockdown cell monolayers in both the presence and the absence of a P-gp inhibitor.
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This assay is used to determine the BCRP interaction with a test compound using CellPort™ CPT-B1 BCRP-knockdown cell monolayers and wild-type Caco-2 cell monolayers.
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A unique, more definitive test system for identifying BCRP and P-gp substrates
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Services and products based on the novel, proprietary CellPort Technologies
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Introduction to CellPort Technologies, a more definitive drug transporter assay system
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In vitro testing to identify P-gp substrates, inhibitors and inducers
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